Redox-driven deracemization of secondary alcohols by sequential ether/O2-mediated oxidation and Ru-catalyzed asymmetric reduction was written by Yang, Bing;Cui, Peng;Chen, Yongsheng;Liu, Qixing;Zhou, Haifeng. And the article was included in Tetrahedron Letters in 2020.Safety of (S)-1-(2-Fluorophenyl)ethanol This article mentions the following:
The deracemization of secondary alcs. had been achieved using a redox-driven one-pot two-step process. The racemic alcs. were oxidized by bis(methoxypropyl) ether and oxygen to gave the ketone intermediates, followed by an asym. transfer hydrogenation with a chiral ruthenium catalyst. This compatible oxidation/reduction process gave the enantiomerically enriched alcs. such as RCH(OH)R1 [R = Ph, 2-FC6H4, 3-thienyl, etc.; R1 = Me, pentyl, CO2Me, Ph] with up to 95% ee values. In the experiment, the researchers used many compounds, for example, (S)-1-(2-Fluorophenyl)ethanol (cas: 171032-87-4Safety of (S)-1-(2-Fluorophenyl)ethanol).
(S)-1-(2-Fluorophenyl)ethanol (cas: 171032-87-4) belongs to alcohols. Alcohols are weak acids. The most acidic simple alcohols (methanol and ethanol) are about as acidic as water, and most other alcohols are somewhat less acidic. Tertiary alcohols cannot be oxidized at all without breaking carbon-carbon bonds, whereas primary alcohols can be oxidized to aldehydes or further oxidized to carboxylic acids.Safety of (S)-1-(2-Fluorophenyl)ethanol
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts