Palladium-Catalyzed Oxidative Nonclassical Heck Reaction of Arylhydrazines with Allylic Alcohols via C-N Bond Cleavage: Access to β-Arylated Carbonyl Compounds was written by Wang, Xiaoshuo;Wang, Xiaojing;Pan, Hongwu;Ming, Xiayi;Zhang, Zhenming;Wang, Tao. And the article was included in Journal of Organic Chemistry in 2022.Computed Properties of C8H16O This article mentions the following:
An efficient palladium-catalyzed oxidative nonclassical Heck reaction of arylhydrazines with allylic alcs. via C-N bond cleavage to form β-arylated carbonyl compounds I [R = Me, Et, Cy, etc.; R1 = Ph, pentyl] was successfully developed. This method provided a series of β-arylated carbonyl compounds I with broad functional group tolerance under base-free, simple, and mild open air reaction conditions. In the reaction, arylhydrazines with the smaller mol. weight of the leaving group were employed as the “green”; arylation reagent, which released N2 and water as the byproducts under air. Mechanistic studies suggested that an aryl radical process and Pd-H complex migration reinsertion were involved. Moreover, the synthesis of the antiarrhythmic drug propafenone was completed with this transformation as the key step. In the experiment, the researchers used many compounds, for example, Oct-1-en-3-ol (cas: 3391-86-4Computed Properties of C8H16O).
Oct-1-en-3-ol (cas: 3391-86-4) belongs to alcohols. Similar to water, an alcohol can be pictured as having an sp3 hybridized tetrahedral oxygen atom with nonbonding pairs of electrons occupying two of the four sp3 hybrid orbitals. Grignard and organolithium reagents are powerful tools for organic synthesis, and the most common products of their reactions are alcohols.Computed Properties of C8H16O
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts