Evaluation of cosmetic creams containing Black cumin (Nigella sativa)-Lemon balm (Melissa officinalis L.)-Aloe vera (Aloe barbadensis miller) essences by modeling with Box Behnken method in Design Expert was written by Turedi, Ece;Acarali, Nil. And the article was included in Industrial Crops and Products in 2022.Reference of 499-75-2 This article mentions the following:
In this investigation regarding medicinal and aromatic plants, an exptl. study was conducted on the effectiveness of black cumin, lemon balm and Aloe vera essences in cosmetic creams, which were selected for their beneficial biol. activities such as anti-inflammatory, moisturizing, etc. In line with this study stability test, which was important in the quality evaluation of cosmetic products, was carried out. Cream samples containing different concentrations of black cumin and lemon balm essences were kept at under 3 different temperature conditions as 0 °C, 25 °C and 40 °C and the necessary values were recorded. In this direction, the effects of the temperature on the phys. and chem. properties of the cosmetic creams were assessed. Homogenization and colors as phys. properties and pH value of the herbal cream samples were examined It was observed that the pH value, which was an important parameter for skin care products, was 6.5 under the optimum exptl. condition and it was an acceptable value for skin creams according to the literature. In the second part of the exptl. study, the effect of the essence obtained from the Aloe vera plant on the samples was tested with the optimum condition selected from 17 different exptl. sets by using the Design Expert optimization application. In addition, from the production of cosmetic products; it was necessary to pay attention to the environmental conditions stipulated in storage, transportation, and sales points. As a result of the tests, it was seen that the medicinal and aromatic plants used could be evaluated in the field of cosmetics and successful results could be obtained. In the experiment, the researchers used many compounds, for example, 5-Isopropyl-2-methylphenol (cas: 499-75-2Reference of 499-75-2).
5-Isopropyl-2-methylphenol (cas: 499-75-2) belongs to alcohols. A strong base can deprotonate an alcohol to yield an alkoxide ion (R―O−). For example, sodamide (NaNH2), a very strong base, abstracts the hydrogen atom of an alcohol. Converting an alcohol to an alkene requires removal of the hydroxyl group and a hydrogen atom on the neighbouring carbon atom. Dehydrations are most commonly carried out by warming the alcohol in the presence of a strong dehydrating acid, such as concentrated sulfuric acid.Reference of 499-75-2
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts