Sulfur-Rich Zinc Chemistry: New Tris(thioimidazolyl)hydroborate Ligands and Their Zinc Complex Chemistry Related to the Structure and Function of Alcohol Dehydrogenase was written by Tesmer, Markus;Shu, Mouhai;Vahrenkamp, Heinrich. And the article was included in Inorganic Chemistry in 2001.Formula: C7H9NO This article mentions the following:
The 1-substituted tris(2-thioimidazolyl)hydroborate ligands TtR were prepared as the K salts from KBH4 and the corresponding 1-R-2-thioxoimidazole for R = t-Bu and C6H4-p-CHMe2 (Cum). Their reactions with Zn salts yielded the tetrahedral complexes TtRZn-X with X = F, Cl, ONO2 and (Ttt-Bu)2Zn. With Zn(ClO4)2 the labile perchlorate complexes TtRZn-OClO3 were obtained. They served as starting materials for the incorporation of substrates which are relevant for the chem. of horse liver alc. dehydrogenase: EtOH led to [Ttt-BuZn·EtOH] ClO4·EtOH, p-nitrophenol (NitOH) yielded TtCumZn-ONit. Pyridine-2-carbaldehyde and salicylaldehyde were incorporated as N(pyridine) and O(phenolate) coligands with possible addnl. O(aldehyde) coordination. Substituted pyridylmethanols (R-PyCH2OH) yielded trinuclear [(Ttt-Bu)2Zn3(R-PyCH2O)2](ClO4)2 with bridging Tt and pyridylmethoxide ligands. Preliminary experiments on the functional modeling of alc. dehydrogenase showed that TtZn complexes promote both the dehydrogenation of iso-PrOH and the hydrogenation of pentafluorobenzaldehyde. In the experiment, the researchers used many compounds, for example, 6-Methyl-2-pyridinemethanol (cas: 1122-71-0Formula: C7H9NO).
6-Methyl-2-pyridinemethanol (cas: 1122-71-0) belongs to alcohols. Alcohols are among the most common organic compounds. They are used as sweeteners and in making perfumes, are valuable intermediates in the synthesis of other compounds, and are among the most abundantly produced organic chemicals in industry. Converting an alcohol to an alkene requires removal of the hydroxyl group and a hydrogen atom on the neighbouring carbon atom. Dehydrations are most commonly carried out by warming the alcohol in the presence of a strong dehydrating acid, such as concentrated sulfuric acid.Formula: C7H9NO
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts