Synthesis and SAR of tolylamine 5-HT6 antagonists was written by Singer, Jamie M.;Wilson, Michael W.;Johnson, Paul D.;Graham, Shelley R.;Cooke, Leonard W.;Roof, Robin L.;Boxer, Peter A.;Gold, Lisa H.;Meltzer, Leonard T.;Janssen, Ann;Roush, Nicole;Campbell, Jeffrey E.;Su, Ti-Zhi;Hurst, Susan I.;Stoner, Chad L.;Schwarz, Jacob B.. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2009.Recommanded Product: 120121-01-9 This article mentions the following:
The synthesis and SAR of tolylamines with 5-HT6 receptor antagonist activity was presented. The amine, core aromatic, peripheral aromatic, and ether linker moieties of an HTS hit were modulated and the effect on potency at 5-HT6 examined Tolylpiperidine ether I was found to possess desirable pharmacokinetic properties, and was also shown to enhance cognition in the rat novel object recognition paradigm. In the experiment, the researchers used many compounds, for example, (R)-1-(3-Chlorophenyl)ethanol (cas: 120121-01-9Recommanded Product: 120121-01-9).
(R)-1-(3-Chlorophenyl)ethanol (cas: 120121-01-9) belongs to alcohols. Alkyl halides are often synthesized from alcohols, in effect substituting a halogen atom for the hydroxyl group. Tertiary alcohols cannot be oxidized at all without breaking carbon-carbon bonds, whereas primary alcohols can be oxidized to aldehydes or further oxidized to carboxylic acids.Recommanded Product: 120121-01-9
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts