Synthesis and biological studies of novel 2-aminoalkyl ethers as potential antiarrhythmic agents for the conversion of atrial fibrillation was written by Plouvier, Bertrand;Beatch, Gregory N.;Jung, Grace L.;Zolotoy, Alexander;Sheng, Tao;Clohs, Lilian;Barrett, Terrance D.;Fedida, David;Wang, Wei Q.;Zhu, Jeff J.;Liu, Yuzhong;Abraham, Shlomo;Lynn, Leah;Dong, Ying;Wall, Richard A.;Walker, Michael J. A.. And the article was included in Journal of Medicinal Chemistry in 2007.Recommanded Product: 2-(Trifluoromethyl)phenethyl alcohol This article mentions the following:
A series of 2-aminoalkyl ethers R1R2NCHR3CHR4O(CH2)nCHR5R6 (I) [n = 1 – 3; R1 = R2 = MeOCH2CH2; R1R2N = 4-morpholinyl, 1-piperazinyl, 3-oxo-1-pyrrolidinyl, etc.; R3 = H, R4 = n-Bu; R3R4 = (CH2)3, (CH2)4; R5 = H, Ph; R6 = 1-naphthyl, 2-naphthyloxy, 4-BrC6H4, 3-benzothienyl, etc.] was prepared as potential antiarrhythmic agents. These compounds are mixed sodium and potassium ion channel blockers and exhibit antiarrhythmic activity in a rat model of ischemia-induced arrhythmias. Structure-activity studies led to the identification of three compounds I [n = 1; R1R2N = 4-morpholinyl; R3R4 = (CH2)4; R5 = H; R6 = 1-naphthyl, 3,4-Cl2C6H3] and I [n = 1; R1R2 = 3-oxo-1-pyrrolidinyl; R3R4 = (CH2)4; R5 = H; R6 = 1-naphthyl; (II)], which were selected based on their particular in vivo electrophysiol. properties, for studies in two canine atrial fibrillation (AF) models. These three compounds converted AF in both models, but only compound II was shown to be orally bioavailable. Resolution of the racemate II into its corresponding enantiomers and subsequent biol. testing of these enantiomers led to the selection of (1S,2S)-II as a potential atrial selective antiarrhythmic candidate for further development. In the experiment, the researchers used many compounds, for example, 2-(Trifluoromethyl)phenethyl alcohol (cas: 94022-96-5Recommanded Product: 2-(Trifluoromethyl)phenethyl alcohol).
2-(Trifluoromethyl)phenethyl alcohol (cas: 94022-96-5) belongs to alcohols. Under appropriate conditions, inorganic acids also react with alcohols to form esters. To form these esters, a wide variety of specialized reagents and conditions can be used. A multistep synthesis may use Grignard-like reactions to form an alcohol with the desired carbon structure, followed by reactions to convert the hydroxyl group of the alcohol to the desired functionality.Recommanded Product: 2-(Trifluoromethyl)phenethyl alcohol
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts