A One-Pot/Single-Analysis Approach to Substrate Scope Investigations Using Comprehensive Two-Dimensional Gas Chromatography (GC×GC) was written by O’Neil, Gregory W.;Nelson, Robert K.;Wright, Alicia M.;Reddy, Christopher M.. And the article was included in Journal of Organic Chemistry in 2016.Formula: C8H9ClO This article mentions the following:
A representative substrate scope study for an enantioselective catalytic ketone-reduction was performed as a single reaction on a mixture containing equimolar amounts of nine (9) prototypical compounds The resulting analyte pool containing 18 potential products from nine different reactions could all be completely resolved in a single chromatog. injection using comprehensive two-dimensional gas chromatog. (GC×GC) with time-of-flight mass spectrometry, allowing for simultaneous determination of percent conversion and enantiomeric excess for each substrate. The results obtained for an enantioselective iron-catalyzed asym. transfer hydrogenation using this 1-pot/single-anal. approach were similar to those reported for the individualized reactions, demonstrating the utility of this strategy for streamlining substrate scope studies. Also, for this particular catalyst, activity and selectivity were not greatly affected by the presence of other ketones or enantioenriched reduced products. This approach allows for faster and greener analyses that are central to new reaction development, as well as an opportunity to gain further insights into other established transformations. In the experiment, the researchers used many compounds, for example, (R)-1-(3-Chlorophenyl)ethanol (cas: 120121-01-9Formula: C8H9ClO).
(R)-1-(3-Chlorophenyl)ethanol (cas: 120121-01-9) belongs to alcohols. Alcohols are among the most common organic compounds. They are used as sweeteners and in making perfumes, are valuable intermediates in the synthesis of other compounds, and are among the most abundantly produced organic chemicals in industry. Converting an alcohol to an alkene requires removal of the hydroxyl group and a hydrogen atom on the neighbouring carbon atom. Dehydrations are most commonly carried out by warming the alcohol in the presence of a strong dehydrating acid, such as concentrated sulfuric acid.Formula: C8H9ClO
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts