Assembly of 4H-chromenes, imidazobenzothiazines and quinazolines via copper-catalyzed domino reactions using 2-halobenzyl tosylates as substrates was written by Omar, Mohamed A.;Conrad, Juergen;Beifuss, Uwe. And the article was included in Tetrahedron in 2014.SDS of cas: 60666-70-8 This article mentions the following:
The use of 2-halobenzyl tosylates as substrates in copper-catalyzed domino intermol. substitution/intramol. arylation processes for the efficient and selective preparation of heterocycles is reported for the first time. Reaction of 2-halobenzyl tosylates with β-ketoesters delivers 4H-chromenes with yields ranging between 59 and 89%. Imidazobenzothiazines are formed with yields up to 82% upon reaction of 2-halobenzyl tosylates with 2-mercaptoimidazoles. When 2-halobenzyl tosylates are reacted with benzamidines the corresponding quinazolines are obtained. In the experiment, the researchers used many compounds, for example, (2-Bromo-5-chlorophenyl)methanol (cas: 60666-70-8SDS of cas: 60666-70-8).
(2-Bromo-5-chlorophenyl)methanol (cas: 60666-70-8) belongs to alcohols. Alcohols are weak acids. The most acidic simple alcohols (methanol and ethanol) are about as acidic as water, and most other alcohols are somewhat less acidic. Under carefully controlled conditions, simple alcohols can undergo intermolecular dehydration to give ethers. This reaction is effective only with methanol, ethanol, and other simple primary alcohols.SDS of cas: 60666-70-8
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts