Design, Synthesis, and Evaluation of Substituted Phenylpropanoic Acid Derivatives as Human Peroxisome Proliferator Activated Receptor Activators. Discovery of Potent and Human Peroxisome Proliferator Activated Receptor α Subtype-Selective Activators was written by Nomura, Masahiro;Tanase, Takahiro;Ide, Tomohiro;Tsunoda, Masaki;Suzuki, Masahiro;Uchiki, Hideharu;Murakami, Koji;Miyachi, Hiroyuki. And the article was included in Journal of Medicinal Chemistry in 2003.SDS of cas: 2968-93-6 This article mentions the following:
Substituted phenylpropanoic acid derivatives such as I are prepared as selective human peroxisome proliferator activated receptor α (PPARα) activators. Structure-activity relationships for the binding of a variety of substituted phenylpropanoic acid derivatives to human peroxisome proliferator activated receptors are determined The nature and the stereochem. of the substituent at the α-position of the head part containing the carboxyl group, the distance between the carboxyl group and the central benzene ring, the linking group between the central benzene ring and the distal benzene ring, and the substituent at the distal hydrophobic tail part of the mol. all play key roles in determining the potency and selectivity of PPAR subtype transactivation. Mol. mechanics calculations of the conformers of phenylpropanoic acid derivatives and of the enantiomers of an α-ethyl-substituted phenylpropanoic acid derivative are discussed. I is a particularly effective PPARα activator with significant selectivity for PPARα. In rats, I decreases serum cholesterol and lipids over five days of administration in a dose-dependent manner and with a significantly greater efficacy than a representative fibrate (bezafibrate) used for comparison. Phenylpropanoic acid II is found to be a dual activator of PPARα and of PPARδ. In the experiment, the researchers used many compounds, for example, 2-(4-(Trifluoromethyl)phenyl)ethanol (cas: 2968-93-6SDS of cas: 2968-93-6).
2-(4-(Trifluoromethyl)phenyl)ethanol (cas: 2968-93-6) belongs to alcohols. Alcohols are weak acids. The most acidic simple alcohols (methanol and ethanol) are about as acidic as water, and most other alcohols are somewhat less acidic. Grignard and organolithium reagents are powerful tools for organic synthesis, and the most common products of their reactions are alcohols.SDS of cas: 2968-93-6
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts