Host-guest complexation. 3. Organization of pyridyl binding sites was written by Newcomb, Martin;Timko, Joseph M.;Walba, David M.;Cram, Donald J.. And the article was included in Journal of the American Chemical Society in 1977.Recommanded Product: 6-Methyl-2-pyridinemethanol This article mentions the following:
Six new multiheteromacrocycles were prepared containing as part of the major ring system from one to four 2,6-pyridinedimethylyl units. The pKa of these compounds were comparable to those of open-chain models except for that of sym-dipyridyl-12-crown-4, e.g., I, whose conjugate acid was 4 kcal/mol more stable than the others. The 18-membered cycles, e.g., II, gave free energies of association for complexation with tert-BuNH3SCN in CDCl3 about 5 kcal/mol more neg. (complexes more stable) than either the 12- or the 24-membered ring systems. In CDCl3 for five 18-membered host compounds containing widely different binding units, tert-BuNH3SCN was better complexed than tert-BuNH3Cl by 2.9 ± 0.1 kcal/mol at 0°. Of the 13 possible 18-membered ring pyridocycles containing 6 binding sites that are either O or N, 3 were synthesized. The free energies of complexation of these cycles and 18-crown-6 with tert-BuNH3Cl were determined at 0° and estimated at 24°. The values for 3 of these cycles were dissected into 6 host-guest contact site parameters (4 different kinds) whose addition equaled the free energies of association of host and guest. The parameters taken in appropriate combinations dictated by host structure were then used to calculate the free energies of association of the 4th cycle. The measured and calculated values were in reasonable agreement. The 4 different kinds of free-energy contact site parameters were then used to predict the free energies of association of the remaining unsynthesized 10 cycles. In the experiment, the researchers used many compounds, for example, 6-Methyl-2-pyridinemethanol (cas: 1122-71-0Recommanded Product: 6-Methyl-2-pyridinemethanol).
6-Methyl-2-pyridinemethanol (cas: 1122-71-0) belongs to alcohols. Alkyl halides are often synthesized from alcohols, in effect substituting a halogen atom for the hydroxyl group. The most common reactions of alcohols can be classified as oxidation, dehydration, substitution, esterification, and reactions of alkoxides.Recommanded Product: 6-Methyl-2-pyridinemethanol
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts