Diverse synthesis of C2-linked functionalized molecules via molecular glue strategy with acetylene was written by Yang, Bo;Lu, Shaodong;Wang, Yongdong;Zhu, Shifa. And the article was included in Nature Communications in 2022.Application In Synthesis of (1R,2S,5R)-2-Isopropyl-5-methylcyclohexanol This article mentions the following:
A photoredox-catalyzed synthetic protocol for diverse C2-linked mols. via a mol. glue strategy using gaseous acetylene under mild conditions was developed. Initiated by addition of an acyl radical to acetylene, two cascade transformations follow. One involved a double addition for the formation of 1,4-diketones and the other where the intermediate vinyl ketone was intercepted by a radical formed from a heterocycle. In addition to making two new C-C bonds, two C-H bonds was also created in two mechanistically distinct ways: one via a C-H abstraction and the other via protonation. This system offered a reliable and safe way to incorporate gaseous acetylene into fine chems. and expanded the utility of acetylene in organic synthesis. In the experiment, the researchers used many compounds, for example, (1R,2S,5R)-2-Isopropyl-5-methylcyclohexanol (cas: 2216-51-5Application In Synthesis of (1R,2S,5R)-2-Isopropyl-5-methylcyclohexanol).
(1R,2S,5R)-2-Isopropyl-5-methylcyclohexanol (cas: 2216-51-5) belongs to alcohols. Under appropriate conditions, inorganic acids also react with alcohols to form esters. To form these esters, a wide variety of specialized reagents and conditions can be used. The most common reactions of alcohols can be classified as oxidation, dehydration, substitution, esterification, and reactions of alkoxides.Application In Synthesis of (1R,2S,5R)-2-Isopropyl-5-methylcyclohexanol
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts