Electrochemical α-C(sp3)-H/O-H cross-coupling of isochromans and alcohols assisted by benzoic acid was written by Wang, Zhuang;Niu, Kaikai;Liu, Yuxiu;Song, Hongjian;Wang, Qingmin. And the article was included in Chemical Communications (Cambridge, United Kingdom) in 2022.Formula: C9H9F3O This article mentions the following:
Isochroman moieties are present in a wide variety of biol. active mols., but converting isochromans to α-substituted derivatives under mild conditions is challenging. Herein, authors report a mild, convenient protocol for synthesis of α-alkoxy isochroman derivatives by means of electrochem. α-C(sp3)-H/O-H cross-coupling reactions of isochromans and alcs. in the presence of benzoic acid, which facilitated the electro-oxidation process and increased the product yield. Various alcs. and isochromans, as well as other structurally similar substrates, gave moderate to high yields of the desired coupling products, and the reaction could be carried out on a gram scale. In the experiment, the researchers used many compounds, for example, 2-(Trifluoromethyl)phenethyl alcohol (cas: 94022-96-5Formula: C9H9F3O).
2-(Trifluoromethyl)phenethyl alcohol (cas: 94022-96-5) belongs to alcohols. Because alcohols are easily synthesized and easily transformed into other compounds, they serve as important intermediates in organic synthesis. Converting an alcohol to an alkene requires removal of the hydroxyl group and a hydrogen atom on the neighbouring carbon atom. Dehydrations are most commonly carried out by warming the alcohol in the presence of a strong dehydrating acid, such as concentrated sulfuric acid.Formula: C9H9F3O
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts