Enantioselective Fluorescent Recognition of β-Amino Alcohols by Stereoselective Cyclization was written by Tian, Jun;Yu, Shanshan;Guo, Hongyu;Zhu, Maoshuai;Lu, Kai;Jiang, Yixuan;Yang, Jiaqiao;Yu, Xiaoqi;Pu, Lin. And the article was included in European Journal of Organic Chemistry in 2022.Quality Control of (R)-2-Aminobutan-1-ol This article mentions the following:
2,2′-Diformyl-1,1′-binaphthyl is found to exhibit highly enantioselective fluorescence enhancement in the presence of various β-amino alcs. and base. It provides a new method to determine the enantiomeric composition of those substrates and has potential for high throughput anal. Based on detailed spectroscopic analyses, it is proposed that a stereoselective cyclization of a β-amino alc. with the probe should occur to form a rigid macrocyclic intermediate, contributing to the greatly enhanced fluorescence. In the experiment, the researchers used many compounds, for example, (R)-2-Aminobutan-1-ol (cas: 5856-63-3Quality Control of (R)-2-Aminobutan-1-ol).
(R)-2-Aminobutan-1-ol (cas: 5856-63-3) belongs to alcohols. A strong base can deprotonate an alcohol to yield an alkoxide ion (R―O−). For example, sodamide (NaNH2), a very strong base, abstracts the hydrogen atom of an alcohol. Converting an alcohol to an alkene requires removal of the hydroxyl group and a hydrogen atom on the neighbouring carbon atom. Dehydrations are most commonly carried out by warming the alcohol in the presence of a strong dehydrating acid, such as concentrated sulfuric acid.Quality Control of (R)-2-Aminobutan-1-ol
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts