Novel pyrazole-3-carboxamide derivatives as cannabinoid-1 (CB1) antagonists: Journey from non-polar to polar amides was written by Sasmal, Pradip K.;Reddy, D. Srinivasa;Talwar, Rashmi;Venkatesham, B.;Balasubrahmanyam, D.;Kannan, M.;Srinivas, P.;Kumar, K. Shiva;Devi, B. Neelima;Jadhav, Vikram P.;Khan, Sanjoy K.;Mohan, Priya;Chaudhury, Hira;Bhuniya, Debnath;Iqbal, Javed;Chakrabarti, Ranjan. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2011.Product Details of 42514-50-1 This article mentions the following:
The synthesis and biol. evaluation of novel pyrazole-3-carboxamide derivatives, e.g. I, as CB1 antagonists are described. As a part of eastern amide SAR, various chem. diverse motifs were introduced. In general, a range of modifications were well tolerated. Several mols. with high polar surface area were also identified as potent CB1 receptor antagonists. The in vivo proof of principle for weight loss is exemplified with a lead compound from this series. In the experiment, the researchers used many compounds, for example, 3-Amino-3-methylbutan-1-ol (cas: 42514-50-1Product Details of 42514-50-1).
3-Amino-3-methylbutan-1-ol (cas: 42514-50-1) belongs to alcohols. Alcohols are weak acids. The most acidic simple alcohols (methanol and ethanol) are about as acidic as water, and most other alcohols are somewhat less acidic. Alcohols may be oxidized to give ketones, aldehydes, and carboxylic acids. These functional groups are useful for further reactions. Oxidation of organic compounds generally increases the number of bonds from carbon to oxygen (or another electronegative element, such as a halogen), and it may decrease the number of bonds to hydrogen.Product Details of 42514-50-1
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts