Radioiodinated phenoxyacetic acid derivatives as potential brain imaging agents. I. Efficient synthesis via trimethylsilyl intermediates was written by Ohmomo, Yoshiro;Okuyama, Shinichiro;Magata, Yasuhiro;Ueno, Yoko;Tanaka, Chiaki;Yokoyama, Akira. And the article was included in Chemical & Pharmaceutical Bulletin in 1989.Application In Synthesis of 1-(Dimethylamino)-2-methylpropan-2-ol This article mentions the following:
The usefulness of radioiodination via demetalation of aryltrimethylsilanes is demonstrated. The radioiodination reaction was very rapid and the regiospecific incorporation of radioiodine could be carried out with high radiochem. yields and high radiospecific activity. 125I-labeled iodophenoxyacetate derivatives I (R = 2-, 3-, 4-125Iodo, R1,R2 = H, Me), iodophenoxyacetamide derivatives II (R = 2-, 3-, 4-125Iodo), iodophenoxyethylamino derivatives III (R3 = H, Me), and an iodophenoxyethylpiperazine derivative IV were efficiently synthesized from the aryltrimethylsilyl intermediates, e.g., I and II (R = 2-, 3-, 4-SiMe3) by this method. In the experiment, the researchers used many compounds, for example, 1-(Dimethylamino)-2-methylpropan-2-ol (cas: 14123-48-9Application In Synthesis of 1-(Dimethylamino)-2-methylpropan-2-ol).
1-(Dimethylamino)-2-methylpropan-2-ol (cas: 14123-48-9) belongs to alcohols. A strong base can deprotonate an alcohol to yield an alkoxide ion (R―O−). For example, sodamide (NaNH2), a very strong base, abstracts the hydrogen atom of an alcohol. Converting an alcohol to an alkene requires removal of the hydroxyl group and a hydrogen atom on the neighbouring carbon atom. Dehydrations are most commonly carried out by warming the alcohol in the presence of a strong dehydrating acid, such as concentrated sulfuric acid.Application In Synthesis of 1-(Dimethylamino)-2-methylpropan-2-ol
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts