Synthesis of arylsulfonyl hydrazones and 1-arylsulfonyl-4-substituted thiosemicarbazides was written by Munshi, A. A.;Shah, N. M.;Trivedi, J. P.. And the article was included in Indian Journal of Chemistry in 1963.Application of 2968-93-6 This article mentions the following:
Several arylsulfonyl hydrazines, p-XC6H4SO2NHNH2 (I) were synthesized by the action of N2H4.-H2O on appropriate sulfonyl chlorides. I were condensed with various aldehydes to give the corresponding arylsulfonyl hydrazones, p-XC6H4SO2NHN:CHR (II), and on condensation with various isothiocyanates, I gave 1,4-disubstituted thiosemicarbazides, p-XC6H4SO2NHNHC(S)NHR (III). Thus, 10 g. 50% N2H4. H2O was added to a solution of 9.52 g. p-MeC6H4SO2Cl in 25 mL. C6H6 and the solution stirred ∼2.5 h. to give 65% p-MeC6H4SO2NHNH2, m. 112° (CHCl3). The following I were similarly prepared (X and m.p. given): H, 102°; OMe, 99°; Cl, 128°; and Br, 155-7°. A mixture of 2.02 g. p-MeOC6H4SO2NHNH2, 1.56 g. α-naphthaldehyde, and 0.92 g. fused NaOAc in 20 mL. EtOH was refluxed 2 h. on a water bath and the solution filtered. The filtrate, on evaporation and washing of the residue with dilute HCl and H2O, gave 63% II (X = OMe, R = α-C10H7), m. 147° (EtOH). The following II were similarly prepared (X, R, and m.p. given): H, Ph, 110-14°; H, o-C6H4OH, 157-8°; H, α-C10H7, 123°; H, p-Me2NC6H4, 251-3°; H, 4,3-HO(MeO)C6H3, 90°; H, 2,4-Cl2C6H3, 188-9°; H, p-HOC6H3, 172-3°; Me, Ph, 126°; Me, o-C6H4OH, 199-201°; Me, α-C10H7, 144-6°; Me, p-Me2NC6H4, 96-7°; Me, 4,3-HO(MeO)C6H3, 212°; Me, p-HOC6H4, 215°; Me, 2,4-Cl2C6H3, 213-14°; OMe, Ph, 87-9°; OMe, o-C6H4OH, 215°; OMe, p-Me2NC6H4, 245-8°; OMe, 4,3-HO(MeO)C6H3, 161-3°; OMe, p-HOC6H4, 182-4°; OMe, 2,4-Cl2C6H3, 207-8°; Cl, Ph, 148°; Cl, o-C6H4OH, 146°; Cl, α-C10H7, 144-5°; Cl, p-Me2NC6H4, 102-4°; Cl, 4,3-HO(MeO)C6H3, 147-8°; Cl, p-HOC6H4, 148°; Cl, 2,4-Cl2C6H3, 149-51°; Br, Ph, 163-5°; Br, o-C6H4OH, 208°; Br, α-C10H7, 147°; Br, p-Me2NC6H4, 131°; Br, 4,3-HO(MeO)C6H3, 164°; Br, p-HOC6H4, 169°; and Br, 2,4-Cl2C6H3, 210°. A mixture of 2.51 g. p-BrC6H4SO2NHNH2 and 1.49 g. PhCH2NCO in 15 mL. EtOH was refluxed 1 h. on a water bath. The mixture on cooling gave 2.4 g. III (X = Br, R = PhCH2), m. 201-2° (EtOH). The following III were similarly prepared (X, R, and m.p. given): (In some cases a reflux period of 15-20 min. was found sufficient): H, Ph, 182-4°; H, PhCH2, 198°; H, p-MeC6H4, 197°; H, o-MeC6H4, 201°; H, p-MeOC6H4, 199°; H, Ph3C, 89°; H, p-IC6H4 196°; Me, Ph, 192-5°; Me, PhCH2, 187°; Me, p-MeC6H4, 190°; Me, o-MeC6H4, 185°; Me, p-MeOC6H4, 199°; Me, Ph3C, 91°; Me, p-IC6H4, 235-8°; OMe, Ph, 197°; OMe, PhCH2, 194-6°; OMe, p-MeC6H4, 209°; OMe, o-MeC6H4, 227°; OMe, p-MeOC6H4, 218°; OMe, Ph3C, 97-8°; OMe, p-IC6H4, 264°; Cl, Ph, 226°; Cl, PhCH2, 176°; Cl, p-MeC6H4, 222°; Cl, o-MeC6H4, 151°; Cl, p-MeOC6H4, 209°; Cl, Ph3C, 102°; Cl, p-IC6H4, 212-13°; Br, Ph, 188°; Br, p-MeC6H4, 197°; Br, o-MeC6H4, 174°; Br, p-MeOC6H4, 199°; Br, Ph3C, 95°; and Br, p-IC6H4, 195-7°. In the experiment, the researchers used many compounds, for example, 2-(4-(Trifluoromethyl)phenyl)ethanol (cas: 2968-93-6Application of 2968-93-6).
2-(4-(Trifluoromethyl)phenyl)ethanol (cas: 2968-93-6) belongs to alcohols. Alcohols are among the most common organic compounds. They are used as sweeteners and in making perfumes, are valuable intermediates in the synthesis of other compounds, and are among the most abundantly produced organic chemicals in industry. A multistep synthesis may use Grignard-like reactions to form an alcohol with the desired carbon structure, followed by reactions to convert the hydroxyl group of the alcohol to the desired functionality.Application of 2968-93-6
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts