Water tolerant base free Copper (I) catalyst for the selective aerobic oxidation of primary alcohols was written by Lagerspets, Emi;Abba, Donatella;Sharratt, Joseph;Eronen, Aleksi;Repo, Timo. And the article was included in Molecular Catalysis in 2022.Category: alcohols-buliding-blocks This article mentions the following:
Authors report here a base free copper(I) catalyst for the selective aerobic oxidation of primary alcs. to their corresponding aldehydes and various diols to their corresponding lactones or lactols. In the presence of the in situ generated Cu(I)-catalyst with 2,2′-dipyridylamine (dpa) as a ligand and 2,2,6,6-tetramethylpiperdine-N-oxyl (TEMPO) as a persistent radical, the oxidation reaction proceeds under true aerobic conditions, at ambient temperature, utilizing air as the oxidant and without added base. High catalytic activity without over oxidation was achieved for numerous primary alcs. (aliphatic, allylic, benzylic and diols) with different substitution patterns. The catalyst’s stability is unique among reported Cu(I)-catalysts. It is not moisture or air sensitive, and is capable of e.g. oxidizing aliphatic and benzyl alcs. in a water/acetonitrile solution in moderate or in quant. yield (> 99%) in 3 h. In the experiment, the researchers used many compounds, for example, (4-Chlorophenyl)methanol (cas: 873-76-7Category: alcohols-buliding-blocks).
(4-Chlorophenyl)methanol (cas: 873-76-7) belongs to alcohols. Similar to water, an alcohol can be pictured as having an sp3 hybridized tetrahedral oxygen atom with nonbonding pairs of electrons occupying two of the four sp3 hybrid orbitals. Grignard and organolithium reagents are powerful tools for organic synthesis, and the most common products of their reactions are alcohols.Category: alcohols-buliding-blocks
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts