Immunoprotective potential of Ayurvedic herb Kalmegh (Andrographis paniculata) against respiratory viral infections – LC-MS/MS and network pharmacology analysis was written by Banerjee, Subhadip;Kar, Amit;Mukherjee, Pulok K.;Haldar, Pallab K.;Sharma, Nanaocha;Katiyar, Chandra Kant. And the article was included in Phytochemical Analysis in 2021.Application In Synthesis of (E)-4-(3,5-Dihydroxystyryl)benzene-1,2-diol This article mentions the following:
Immunity boosting has emerged as a global strategy to fight the SARS-CoV-2 pandemic situation. In India, AYUSH systems of medicine have been promoted as an immune-protection strategy. Andrographis paniculata (Burm. F) Nees (AP) mentioned in Ayurveda has been widely used for treating sore throat, flu, and upper respiratory tract infections which may provide possible novel therapeutic approaches, exclusively targeting SARS-CoV-2 and its pathways. The present work uses liquid chromatog.-tandem mass spectrometry (LC-MS/MS) metabolomics and combination synergy anal. based on network pharmacol. to mine multimode evidence to understand the possible mechanism of action, diseases association, protein-protein interaction and major pathways involved therein. Metabolite profiling was performed by Agilent QTOF LC-MS/MS system. Network pharmacol. anal. was performed by using functional annotation anal. based on databases like Binding DB, STRING, DAVID and KEGG for further data mining. Further combination synergy was evaluated using “neighborhood approach” and networks were constructed through Cytoscape 3.2.1. The mols. from kalmegh provides immune-protection and anti-viral response via involving different pathways, like toll-like receptor pathway, PI3/AKT pathway and MAP kinase pathways against COVID-19 infection. The KEGG anal. showed that in a vast majority of the most enriched pathways, AP were associated with viral infections and upper respiratory tract infections. The results suggest a synergy between andrographolide and other mols. identified as safe and efficacious anti-inflammatory agent having effects on upper respiratory tract infections and can significantly decrease the production of cytokines and pro-inflammatory factors in viral infections. In the experiment, the researchers used many compounds, for example, (E)-4-(3,5-Dihydroxystyryl)benzene-1,2-diol (cas: 10083-24-6Application In Synthesis of (E)-4-(3,5-Dihydroxystyryl)benzene-1,2-diol).
(E)-4-(3,5-Dihydroxystyryl)benzene-1,2-diol (cas: 10083-24-6) belongs to alcohols. Alcohols are among the most common organic compounds. They are used as sweeteners and in making perfumes, are valuable intermediates in the synthesis of other compounds, and are among the most abundantly produced organic chemicals in industry. Grignard and organolithium reagents are powerful tools for organic synthesis, and the most common products of their reactions are alcohols.Application In Synthesis of (E)-4-(3,5-Dihydroxystyryl)benzene-1,2-diol
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