Palladium-Mediated Cγ-H Functionalization of Alicyclic Amines was written by Aguilera, Ellen Y.;Sanford, Melanie S.. And the article was included in Angewandte Chemie, International Edition in 2021.Category: alcohols-buliding-blocks This article mentions the following:
This paper describes a new method for the transannular functionalization of the γ-C-H bonds in alicyclic amines to install C(sp3)-halogen, oxygen, nitrogen, boron, and sulfur bonds. The key challenge for this transformation is controlling the relative rate of Cγ-H vs. Cα-H functionalization. We demonstrate that this selectivity can be achieved by pre-complexation of the substrate with Pd prior to the addition of oxidant. This approach enables the use of diverse oxidants that ultimately install various heteroatom functional groups at the γ-position with high site- and diastereoselectivity. In the experiment, the researchers used many compounds, for example, 2,3,4,5-Tetrahydro-1H-1,5-methanobenzo[d]azepine hydrochloride (cas: 230615-52-8Category: alcohols-buliding-blocks).
2,3,4,5-Tetrahydro-1H-1,5-methanobenzo[d]azepine hydrochloride (cas: 230615-52-8) belongs to alcohols. Under appropriate conditions, inorganic acids also react with alcohols to form esters. To form these esters, a wide variety of specialized reagents and conditions can be used. Alcohols may be oxidized to give ketones, aldehydes, and carboxylic acids. These functional groups are useful for further reactions. Oxidation of organic compounds generally increases the number of bonds from carbon to oxygen (or another electronegative element, such as a halogen), and it may decrease the number of bonds to hydrogen.Category: alcohols-buliding-blocks
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts