Ruthenium-catalyzed hydrogenation of aromatic ketones using chiral diamine and monodentate achiral phosphine ligands was written by Wang, Mengna;Zhang, Ling;Sun, Hao;Chen, Qian;Jiang, Jian;Li, Linlin;Zhang, Lin;Li, Li;Li, Chun. And the article was included in Catalysis Communications in 2021.SDS of cas: 171032-87-4 This article mentions the following:
The Ru-catalyzed asym. hydrogenation of ketones with chiral diamine and monodentate achiral phosphine has been developed. A wide range of ketones were hydrogenated to afford the corresponding chiral secondary alcs. in good to excellent enantioselectivities (up to 98.1% ee). In addition, an appropriate mechanism for the asym. hydrogenation was proposed and verified by NMR spectroscopy. In the experiment, the researchers used many compounds, for example, (S)-1-(2-Fluorophenyl)ethanol (cas: 171032-87-4SDS of cas: 171032-87-4).
(S)-1-(2-Fluorophenyl)ethanol (cas: 171032-87-4) belongs to alcohols. A strong base can deprotonate an alcohol to yield an alkoxide ion (R―O−). For example, sodamide (NaNH2), a very strong base, abstracts the hydrogen atom of an alcohol. Tertiary alcohols cannot be oxidized at all without breaking carbon-carbon bonds, whereas primary alcohols can be oxidized to aldehydes or further oxidized to carboxylic acids.SDS of cas: 171032-87-4
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts