Synthesis and conformational study of stereoisomeric 3-benzylperhydro-1,2,3-benzoxathiazine and -benzoxathiazole 2-oxides was written by Viljanen, Tapio;Pihlaja, Kalevi;Fulop, Ferenc. And the article was included in Acta Chemica Scandinavica in 1996.Safety of Trans-2-(benzylamino)cyclohexanol This article mentions the following:
Cis- and trans-fused 3-benzyl-3,4,4a,5,6,7,8,8a-octahydro-1,2,3-benzoxathiazine 2-oxides and 3-benzyl-3H-3a,4,5,6,7,7a-hexahydro-1,2,3-benzoxathiazole 2-oxides have been prepared by means of cyclization of cis- and trans-N-benzyl-2-aminomethyl- and -2-amino-cyclohexanols with thionyl chloride and N-sulfinylamides. Depending on the ring-closure reagent, different ratios of the diastereomers were found. Configurational and conformational assignments were based on the anal. of 1H and 13C NMR spectra. In the experiment, the researchers used many compounds, for example, Trans-2-(benzylamino)cyclohexanol (cas: 40571-86-6Safety of Trans-2-(benzylamino)cyclohexanol).
Trans-2-(benzylamino)cyclohexanol (cas: 40571-86-6) belongs to alcohols. A strong base can deprotonate an alcohol to yield an alkoxide ion (R―O−). For example, sodamide (NaNH2), a very strong base, abstracts the hydrogen atom of an alcohol. A multistep synthesis may use Grignard-like reactions to form an alcohol with the desired carbon structure, followed by reactions to convert the hydroxyl group of the alcohol to the desired functionality.Safety of Trans-2-(benzylamino)cyclohexanol
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts