Selectively Imprinted β-cyclodextrin Polymer for Colorimetric Assay of Lysophosphatidic Acid for Point of Care Detection of Ovarian Cancer was written by Tarannum, Nazia;Kumar, Deepak;Agrawal, Ranu;Verma, Yeshvandra. And the article was included in ChemistrySelect in 2022.Formula: C10H14O5 This article mentions the following:
In the present study, a simple mol. imprinting technique for the quant. measurement of lysophosphatidic acid (LPA) is reported for the first time through colorimetry. LPA is a phospholipid bioactive involved in many physiol. and pathol. processes like stimulating DNA synthesis, proliferating ovarian cancer and inducing cell migration. It is reported that the concentration of LPA in patients with gynecol. cancers like ovarian cancer is considerably higher than in the control. The early diagnosis of ovarian cancer may exceed the survival rate of patients. There is a need for an anal. tool for point of care detection of ovarian cancer at an early stage. Herein, mol. imprinting technique is used to develop an imprinted β-Cyclodextrin (β-CD) polymer using LPA as a template. This MIP prepared was imprinted with an LPA cavity, which has been extended for colorimetry assay. The colorimetric LPA assay was conducted in the spiked blood serum sample. The detection limit of LPA in spiked serum samples is calculated as 0.078 μmol/L. In the experiment, the researchers used many compounds, for example, Diethyleneglycoldiacrylate (cas: 4074-88-8Formula: C10H14O5).
Diethyleneglycoldiacrylate (cas: 4074-88-8) belongs to alcohols. Similar to water, an alcohol can be pictured as having an sp3 hybridized tetrahedral oxygen atom with nonbonding pairs of electrons occupying two of the four sp3 hybrid orbitals. The most common reactions of alcohols can be classified as oxidation, dehydration, substitution, esterification, and reactions of alkoxides.Formula: C10H14O5
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts