Direct and Unified Access to Carbon Radicals from Aliphatic Alcohols by Cost-Efficient Titanium-Mediated Homolytic C-H Bond Cleavage was written by Suga, Takuya;Takahashi, Yuuki;Miki, Chinatsu;Ukaji, Yutaka. And the article was included in Angewandte Chemie, International Edition in 2022.Safety of 2-(4-(Trifluoromethyl)phenyl)ethanol This article mentions the following:
Low-valent Ti-mediated homolytic C-O bond cleavage offers unified access to carbon radicals from ubiquitous non-activated tertiary, secondary, and even primary alcs. In contrast to the representative Ti reagents, which were ineffective for this purpose, “TiCl2(cat)”/Zn (cat=catecholate) was found to be specifically active. This method was applied to the addition reactions of radicals to alkenes and exhibited high generality and yields. More than 50 combinations were examined The excellent cost-efficiency and accessibility of “TiCl2(cat)”/Zn further enhance its applicability. Control experiments proved the presence of a carbon radical intermediate and excluded the pathway via alkyl chlorides. Further mechanistic study indicated that the 1 : 2 complex of alkoxide (R-O-) and TiIII is an active species in the C-O cleavage. In the experiment, the researchers used many compounds, for example, 2-(4-(Trifluoromethyl)phenyl)ethanol (cas: 2968-93-6Safety of 2-(4-(Trifluoromethyl)phenyl)ethanol).
2-(4-(Trifluoromethyl)phenyl)ethanol (cas: 2968-93-6) belongs to alcohols. Because alcohols are easily synthesized and easily transformed into other compounds, they serve as important intermediates in organic synthesis. Grignard and organolithium reagents are powerful tools for organic synthesis, and the most common products of their reactions are alcohols.Safety of 2-(4-(Trifluoromethyl)phenyl)ethanol
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts