Sekar, Balaji Sundara et al. published their research in Advanced Synthesis & Catalysis in 2021 | CAS: 926291-77-2

Bioproduction of Enantiopure (R)- and (S)-2-Phenylglycinols from Styrenes and Renewable Feedstocks was written by Sekar, Balaji Sundara;Mao, Jiwei;Lukito, Benedict Ryan;Wang, Zilong;Li, Zhi. And the article was included in Advanced Synthesis & Catalysis in 2021.Computed Properties of C8H10ClNO This article mentions the following:

Enantiopure (R)- and (S)-2-phenylglycinols are important chiral building blocks for pharmaceutical manufacturing Several chem. and enzymic methods for their synthesis were reported, either involving multi-step synthesis or starting from a relatively complex chem. Here, we developed one-pot simple syntheses of enantiopure (R)- and (S)-2-phenylglycinols from cheap starting materials and renewable feedstocks. Enzyme cascades consisting of epoxidation-hydrolysis-oxidation-transamination were developed to convert styrene to (R)- and (S)-2-phenylglycinol (1a), with butanediol dehydrogenase for alc. oxidation as well as BmTA and NfTA for (R)- and (S)-enantioselective transamination, resp. The engineered E. coli strains expressing the cascades produced 1015 mg/L (R)-1a in >99% ee and 315 mg/L (S)-1a in 91% ee, resp., from styrene. The same cascade also converted substituted styrenes and indene into substituted (R)-phenylglycinols and (1R,2R)-1-amino-2-indanol in 95->99% ee. To transform bio-based L-phenylalanine 6 to (R)-1a and (S)-1a, (R)- and (S)-enantioselective enzyme cascades for deamination-decarboxylation-epoxidation-hydrolysis-oxidation-transamination were developed. The engineered E. coli strains produced (R)-1a and (S)-1a in high ee at 576 mg/L and 356 mg/L, resp., from L-phenylalanine 6, as the first synthesis of these compounds from a bio-based chem. Finally, L-phenylalanine biosynthesis pathway was combined with (R)- or (S)-enantioselective cascade in one strain or coupled strains, to achieve the first synthesis of (R)-1a and (S)-1a from a renewable feedstock. The coupled strain approach enhanced the production, affording 274 and 384 mg/L (R)-1a and 274 and 301 mg/L (S)-1a, from glucose and glycerol, resp. The developed methods could be potentially useful to produce these high-value chems. from cheap starting materials and renewable feedstocks in a green and sustainable manner. In the experiment, the researchers used many compounds, for example, (R)-2-Amino-2-(3-chlorophenyl)ethanol (cas: 926291-77-2Computed Properties of C8H10ClNO).

(R)-2-Amino-2-(3-chlorophenyl)ethanol (cas: 926291-77-2) belongs to alcohols. A strong base can deprotonate an alcohol to yield an alkoxide ion (R―O−). For example, sodamide (NaNH2), a very strong base, abstracts the hydrogen atom of an alcohol. The most common reactions of alcohols can be classified as oxidation, dehydration, substitution, esterification, and reactions of alkoxides.Computed Properties of C8H10ClNO

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts