Synthesis and resolution of Racemic trans-2-(N-benzyl)amino-1-cyclohexanol: enantiomer separation by sequential use of (R)- and (S)-mandelic acid [cyclohexanol, 2-(N-benzyl)amino, (1S,2S)- and (1R,2R)-] was written by Schiffers, Ingo;Bolm, Carsten. And the article was included in Organic Syntheses in 2008.Recommanded Product: Trans-2-(benzylamino)cyclohexanol This article mentions the following:
A method for the synthesis of the title compounds [i.e., (1R,2R)-2-[(phenylmethyl)amino]cyclohexanol and (1S,2S)-2-[(phenylmethyl)amino]cyclohexanol] is reported here. A reaction of cyclohexene oxide [i.e., 7-oxabicyclo[4.1.0]heptane] with benzenemethanamine provided a trans-racemic intermediate [i.e., (1R,2R)-rel-2-[(phenylmethyl)amino]cyclohexanol]. Salt formation of that intermediate with (S)-mandelic acid gave the desired (αS)-α-hydroxybenzeneacetic acid compound with (1R,2R)-2-[(phenylmethyl)amino]cyclohexanol (1:1) as a precipitate The corresponding (αR)-α-hydroxybenzeneacetic acid compound with (1S,2S)-2-[(phenylmethyl)amino]cyclohexanol (1:1) was obtained similarly from the (S,S)-isomer remaining in the filtrate. The above-mentioned title compounds were obtained after hydrolysis and recovery of mandelic acid. In the experiment, the researchers used many compounds, for example, Trans-2-(benzylamino)cyclohexanol (cas: 40571-86-6Recommanded Product: Trans-2-(benzylamino)cyclohexanol).
Trans-2-(benzylamino)cyclohexanol (cas: 40571-86-6) belongs to alcohols. Alkyl halides are often synthesized from alcohols, in effect substituting a halogen atom for the hydroxyl group. Grignard and organolithium reagents are powerful tools for organic synthesis, and the most common products of their reactions are alcohols.Recommanded Product: Trans-2-(benzylamino)cyclohexanol
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