Creatinine recognition using designed synthetic receptors was written by Jana, Subrata;Prajapati, Sunita;Suryavanshi, Kishor Kumar;Goswami, Shyamaprosad;Parida, Rakesh;Giri, Santanab. And the article was included in Journal of Physical Organic Chemistry in 2020.Application In Synthesis of 6-Methyl-2-pyridinemethanol This article mentions the following:
A series of neutral nonenzymic receptors have been synthesized for the recognition of creatinine in a nondegrative way. The receptors contain different heterocyclic moieties for better interactions between host and guest. Among these, 1, 4, and 5 are fluorescent receptors for creatinine. From this study, it was found that the receptors 1 and 4 containing the naphthyridine moiety have higher binding affinity to the guest creatinine than receptors containing other heterocyclic moiety. Theor. studies for the calculation of binding energy were carried out using discrete Fourier transform (DFT) for the hosts and their complexation with creatinine in both gas phase and acetonitrile medium. In the experiment, the researchers used many compounds, for example, 6-Methyl-2-pyridinemethanol (cas: 1122-71-0Application In Synthesis of 6-Methyl-2-pyridinemethanol).
6-Methyl-2-pyridinemethanol (cas: 1122-71-0) belongs to alcohols. Similar to water, an alcohol can be pictured as having an sp3 hybridized tetrahedral oxygen atom with nonbonding pairs of electrons occupying two of the four sp3 hybrid orbitals. Converting an alcohol to an alkene requires removal of the hydroxyl group and a hydrogen atom on the neighbouring carbon atom. Dehydrations are most commonly carried out by warming the alcohol in the presence of a strong dehydrating acid, such as concentrated sulfuric acid.Application In Synthesis of 6-Methyl-2-pyridinemethanol
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts