Oregano essential oil showed limited effects on pigs carcass quality and haematology whereas a transcriptome analysis revealed significant modulations in the jejunum and the ileum was written by Hofmann, Haiko Hendrik;Heusler, Katharina;Roth, Katharina;Proll-Cornelissen, Maren Julia;Grosse-Brinkhaus, Christine;Schellander, Karl;Neuhoff, Christiane. And the article was included in Journal of Animal Physiology and Animal Nutrition in 2022.Computed Properties of C10H14O This article mentions the following:
Pig production depends on a health and performance balance. An approach to improve intestinal health is the oregano essential oil (OEO) supplementation within a conventional diet. Intestinal integrity regulating effects, for example gene expression, of some feed ingredients are important key factors for that balance. We hypothesized that OEO affects the expression of genes associated with pigs intestinal integrity. In four trials, a total of 86 pigs have been used. From weaning, the treated group (n = 42) was addnl. fed an oregano flavor additive [1500 mg/kg (7.5% pure OEO)] within the basal diet. The control group (n = 44) was kept under identical environmental conditions, except the OEO. At age of 6 mo, pigs were slaughtered with an average weight of 111.1 ± 10.9 kg. In addition to automatically generated Fat-o-Meter (AutoFOM) data, carcass quality factors have been measured manually. Valuable cuts of meat, such as ham and belly, were significantly reduced in the OEO group. Effects of OEO on pigs haematol. parameters were very limited. For transcriptome anal., the most interesting microarray expression results have been listed in a table (topTable). Selected genes were tech. validated by qPCR. As a result, few significant differences in animal development and meat quality have been found between the OEO treated and the control group. Depending on OEO supplementation, we found 93 differently regulated genes in the jejunal tissue (70 up, 23 down) and 60 in the ileal tissue (48 up, 12 down). Just three genes (GRIN3B [glutamate ionotropic receptor NMDA type subunit 3B], TJP1/ZO-1 [tight junction protein ZO-1] and one uncharacterized gene) were affected by OEO both in jejunum and ileum. qPCR validation revealed AKT serine/threonine kinase 3 (AKT3), Interferon (IFN) -ε, -ω, tight junction protein (TJP1)/ZO-1 (ZO-1) to be upregulated in the jejunum and C-C motif chemokine ligand 21 (CCL21) was upregulated in the ileum of pigs that were supplemented with OEO. OEO supplementation had limited effects on pigs performance traits. However, we were able to demonstrate that OEO alters the expression of genes associated with adaptive immune response in pigs small intestine. These findings help to explain OEOs beneficial impact on pigs intestinal integrity. In the experiment, the researchers used many compounds, for example, 5-Isopropyl-2-methylphenol (cas: 499-75-2Computed Properties of C10H14O).
5-Isopropyl-2-methylphenol (cas: 499-75-2) belongs to alcohols. Because alcohols are easily synthesized and easily transformed into other compounds, they serve as important intermediates in organic synthesis. Tertiary alcohols cannot be oxidized at all without breaking carbon-carbon bonds, whereas primary alcohols can be oxidized to aldehydes or further oxidized to carboxylic acids.Computed Properties of C10H14O
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