Hansen, Camilla P. et al. published their research in Journal of Medicinal Chemistry in 2008 | CAS: 42514-50-1

3-Amino-3-methylbutan-1-ol (cas: 42514-50-1) belongs to alcohols. Because alcohols are easily synthesized and easily transformed into other compounds, they serve as important intermediates in organic synthesis. Tertiary alcohols cannot be oxidized at all without breaking carbon-carbon bonds, whereas primary alcohols can be oxidized to aldehydes or further oxidized to carboxylic acids.Related Products of 42514-50-1

Novel Acetylcholine and Carbamoylcholine Analogues: Development of a Functionally Selective α4β2 Nicotinic Acetylcholine Receptor Agonist was written by Hansen, Camilla P.;Jensen, Anders A.;Christensen, Jeppe K.;Balle, Thomas;Liljefors, Tommy;Frolund, Bente. And the article was included in Journal of Medicinal Chemistry in 2008.Related Products of 42514-50-1 This article mentions the following:

A series of carbamoylcholine and acetylcholine analogs were synthesized and characterized pharmacol. at neuronal nicotinic acetylcholine receptors (nAChRs). Several of the compounds displayed low nanomolar binding affinities to the α4β2 nAChR and pronounced selectivity for this subtype over α3β4, α4β4, and α7 nAChRs. The high nAChR activity of carbamoylcholine analog I oxalic acid salt was found to reside in its R-enantiomer, a characteristic most likely true for all other compounds in the series. Interestingly, the pronounced α4β2 selectivities exhibited by some of the compounds in the binding assays translated into functional selectivity. Compound II oxalic acid was a fairly potent partial α4β2 nAChR agonist with negligible activities at the α3β4 and α7 subtypes, thus being one of the few truly functionally selective α4β2 nAChR agonists published to date. Ligand-protein docking experiments using homol. models of the amino-terminal domains of α4β2 and α3β4 nAChRs identified residues Val111(β2)/Ile113(β4), Phe119(β2)/Gln121(β4), and Thr155(α4)/Ser150(α3) as possible key determinants of the α4β2/α3β4-selectivity displayed by the analogs. In the experiment, the researchers used many compounds, for example, 3-Amino-3-methylbutan-1-ol (cas: 42514-50-1Related Products of 42514-50-1).

3-Amino-3-methylbutan-1-ol (cas: 42514-50-1) belongs to alcohols. Because alcohols are easily synthesized and easily transformed into other compounds, they serve as important intermediates in organic synthesis. Tertiary alcohols cannot be oxidized at all without breaking carbon-carbon bonds, whereas primary alcohols can be oxidized to aldehydes or further oxidized to carboxylic acids.Related Products of 42514-50-1

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts