Facile Access to Challenging ortho-Terphenyls via Merging Two Multi-Step Domino Reactions in One-Pot: A Joint Experimental/Theoretical Study was written by Grau, Benedikt W.;Boenisch, Simon;Neuhauser, Alexander;Hampel, Frank;Goerling, Andreas;Tsogoeva, Svetlana B.. And the article was included in ChemCatChem in 2019.Related Products of 2968-93-6 This article mentions the following:
A straightforward and sustainable synthesis of highly functionalized ortho-terphenyls I (R = CN, ethoxycarbonyl; R1 = H, F, OMe, Me, etc.; Ar = Ph, furan-3-y, 4-(diphenylamino)phenyl, etc.) via joining an organocatalyzed two-step domino reaction (Knoevenagel/vinylogous Michael) with a DABCO/CuBr2 co-catalyzed three-step domino reaction (cyclization/tautomerization/aromatization) in a one-pot process was demonstrated. Overcoming necessity to isolate intermediate products leads to a reduction of energy, costs and waste for a broad scope of reactions. DFT calculations have been performed to investigate the thermodn. of this one-pot process towards ortho-terphenyls I and to study the reaction profile of the vinylogous Michael reaction under inclusion of solvent effects. Role of London dispersion forces in this transformation has been elucidated. It is shown that reaction kinetics and thermodn. are slightly influenced by dispersion interactions. Furthermore, the addition of dispersion energy donors leads to small changes of reaction energies in some cases. In the experiment, the researchers used many compounds, for example, 2-(4-(Trifluoromethyl)phenyl)ethanol (cas: 2968-93-6Related Products of 2968-93-6).
2-(4-(Trifluoromethyl)phenyl)ethanol (cas: 2968-93-6) belongs to alcohols. Alkyl halides are often synthesized from alcohols, in effect substituting a halogen atom for the hydroxyl group. A multistep synthesis may use Grignard-like reactions to form an alcohol with the desired carbon structure, followed by reactions to convert the hydroxyl group of the alcohol to the desired functionality.Related Products of 2968-93-6
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Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts