Synthesis, Structural Characterization and Anti-Proliferative Activity of (κ1-C)- and (κ2-C,S)-PtII Complexes Bearing Thioether-Functionalized N-Heterocyclic Carbenes was written by Egly, Julien;Bouche, Mathilde;Chen, Weighang;Maisse-Francois, Aline;Achard, Thierry;Bellemin-Laponnaz, Stephane. And the article was included in European Journal of Inorganic Chemistry in 2018.Safety of Sodium 2-methyl-2-propanethiolate This article mentions the following:
A series of platinum(II) complexes bearing thioether-functionalized N-heterocyclic carbene ligands have been synthesized and characterized. The hemilabile and reversible character (i.e., coordination/decoordination) of the sulfur moiety in these platinum complexes has been established by ligand displacement (addition of pyridine) and ligand abstraction (on silica gel). The chem. reactivity of these complexes with glutathione has been investigated by NMR spectroscopy and mass spectrometry. Their biol. activity towards various human cancer cells has been studied; these S-functionalized NHC-platinum complexes displayed moderate cytotoxicity. In the experiment, the researchers used many compounds, for example, Sodium 2-methyl-2-propanethiolate (cas: 29364-29-2Safety of Sodium 2-methyl-2-propanethiolate).
Sodium 2-methyl-2-propanethiolate (cas: 29364-29-2) belongs to alcohols. Because alcohols are easily synthesized and easily transformed into other compounds, they serve as important intermediates in organic synthesis. Alcohols may be oxidized to give ketones, aldehydes, and carboxylic acids. These functional groups are useful for further reactions. Oxidation of organic compounds generally increases the number of bonds from carbon to oxygen (or another electronegative element, such as a halogen), and it may decrease the number of bonds to hydrogen.Safety of Sodium 2-methyl-2-propanethiolate
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts