Vasorelaxant effect of monoterpene carvacrol on isolated human umbilical artery was written by Djukanovic, Djordje;Bojic, Milica Gajic;Marinkovic, Sonja;Trailovic, Sasa;Stojiljkovic, Milos P.;Skrbic, Ranko. And the article was included in Canadian Journal of Physiology and Pharmacology in 2022.Formula: C10H14O This article mentions the following:
Carvacrol (CRV) is the main compound of essential oils extracted primarily from Thymus and Origanum species. Its various biol. activities were confirmed: antioxidant, anti-inflammatory, antibacterial, antifungal, anti-tumor, antinematodal, and vasorelaxant action. Although vasodilation mediated by CRV was previously described, the exact mechanism of its action has not yet been established. Hence, the aim of this study was to investigate CRV vasoactivity on human umbilical arteries (HUA) and the different pathways involved in its mechanism of action using the tissue bath methodol. CRV caused a significant decrease in vascular tension of 5-HT-pre-contracted umbilical arteries, with EC50 of 442.13 ± 33.8 μmol/L (mean ± standard error of the mean-SEM). At 300 μmol/L, CRV shifted downward the 5-HT concentration-response curve with a statistical significance of p < 0.001 obtained for the four highest concentrations At a concentration of 1 mmol/L, CRV completely abolished BaCl2-induced contraction in Ca2+-free Krebs-Ringer bicarbonate solution and the BAY K 8644-induced contraction in Krebs-Ringer bicarbonate solution (p < 0.001). Isopentenyl pyrophosphate, the antagonist of TRPV3 channel, was able to decrease the efficacy of CRV (p < 0.001). The blocking of L-type Ca2+ channels on smooth muscle cells is the most probable mechanism of CRV-induced vasorelaxation. However, the role of TRPV3 channels in CRV-induced vasodilation of HUA cannot be excluded either. In the experiment, the researchers used many compounds, for example, 5-Isopropyl-2-methylphenol (cas: 499-75-2Formula: C10H14O).
5-Isopropyl-2-methylphenol (cas: 499-75-2) belongs to alcohols. Under appropriate conditions, inorganic acids also react with alcohols to form esters. To form these esters, a wide variety of specialized reagents and conditions can be used. Secondary alcohols are easily oxidized without breaking carbon-carbon bonds only as far as the ketone stage. No further oxidation is seen except under very stringent conditions.Formula: C10H14O
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts