ZrCl4 as a new and efficient catalyst for the opening of epoxide rings by amines was written by Chakraborti, Asit K.;Kondaskar, Atul. And the article was included in Tetrahedron Letters in 2003.Application of 40571-86-6 This article mentions the following:
Zirconium(IV) chloride catalyzes the nucleophilic opening of epoxide rings by amines leading to the efficient synthesis of β-amino alcs. The reaction works well with aromatic and aliphatic amines in short times at room temperature in the absence of solvent. Exclusive trans stereoselectivity is observed for cyclic epoxides. Aromatic amines exhibit excellent regioselectivity for preferential nucleophilic attack at the sterically less hindered position during the reaction with unsym. epoxides. However, in case of styrene oxide, selective formation of the benzylic amine was observed during the reactions with aromatic amines. In the experiment, the researchers used many compounds, for example, Trans-2-(benzylamino)cyclohexanol (cas: 40571-86-6Application of 40571-86-6).
Trans-2-(benzylamino)cyclohexanol (cas: 40571-86-6) belongs to alcohols. Under appropriate conditions, inorganic acids also react with alcohols to form esters. To form these esters, a wide variety of specialized reagents and conditions can be used. Under carefully controlled conditions, simple alcohols can undergo intermolecular dehydration to give ethers. This reaction is effective only with methanol, ethanol, and other simple primary alcohols.Application of 40571-86-6
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts