Discovery of SCH446211 (SCH6): A New Ketoamide Inhibitor of the HCV NS3 Serine Protease and HCV Subgenomic RNA Replication was written by Bogen, Stephane L.;Arasappan, Ashok;Bennett, Frank;Chen, Kevin;Jao, Edwin;Liu, Yi-Tsung;Lovey, Raymond G.;Venkatraman, Srikanth;Pan, Weidong;Parekh, Tajel;Pike, Russel E.;Ruan, Sumei;Liu, Rong;Baroudy, Bahige;Agrawal, Sony;Chase, Robert;Ingravallo, Paul;Pichardo, John;Prongay, Andrew;Brisson, Jean-Marc;Hsieh, Tony Y.;Cheng, Kuo-Chi;Kemp, Scott J.;Levy, Odile E.;Lim-Wilby, Marguerita;Tamura, Susan Y.;Saksena, Anil K.;Girijavallabhan, Viyyoor;Njoroge, F. George. And the article was included in Journal of Medicinal Chemistry in 2006.Name: Sodium 2-methyl-2-propanethiolate This article mentions the following:
Introduction of various modified prolines at P2 and optimization of the P1 side chain led to the discovery of SCH6 (24, Table 2), a potent ketoamide inhibitor of the HCV NS3 serine protease. In addition to excellent enzyme potency (Ki*= 3.8 nM), 24 was also found to be a potent inhibitor of HCV subgenomic RNA replication with IC50 and IC90 of 40 and 100 nM, resp. Recently, antiviral activity of 24 was demonstrated with inhibition of the full-length genotype 2a HCV genome. In addition, 24 was found to restore the responsiveness of the interferon regulatory factor 3 (IRF-3) in cells containing HCV RNA replicons. In the experiment, the researchers used many compounds, for example, Sodium 2-methyl-2-propanethiolate (cas: 29364-29-2Name: Sodium 2-methyl-2-propanethiolate).
Sodium 2-methyl-2-propanethiolate (cas: 29364-29-2) belongs to alcohols. Alkyl halides are often synthesized from alcohols, in effect substituting a halogen atom for the hydroxyl group. Grignard and organolithium reagents are powerful tools for organic synthesis, and the most common products of their reactions are alcohols.Name: Sodium 2-methyl-2-propanethiolate
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