Synthesis, biological evaluation and molecular modeling of 1,2,3-triazole analogs of combretastatin A-1 was written by Akselsen, Oyvind W.;Odlo, Kristin;Cheng, Jing-Jy;Maccari, Giorgio;Botta, Maurizio;Hansen, Trond Vidar. And the article was included in Bioorganic & Medicinal Chemistry in 2012.Quality Control of Benzo[d][1,3]dioxol-4-ol This article mentions the following:
The synthesis, cytotoxicity, inhibition of tubulin polymerization data and anti-angiogenetic effects of seven 1,5-disubstituted 1,2,3-triazole analogs and two 1,4-disubstituted 1,2,3-triazole analogs of combretastatin A-1 are reported herein. The biol. studies revealed that the 1,5-disubstituted 1,2,3-triazoles 3-methoxy-6-(1-(3,4,5-trimethoxyphenyl)-1H-1,2,3-triazol-5-yl)benzene-1,2-diol, 3-methoxy-6-(1-(3,4,5-trimethoxyphenyl)-1H-1,2,3-triazol-5-yl)benzene-1,2-diamine and 5-(2,3-difluoro-4-methoxyphenyl)-1-(3,4,5-trimethoxyphenyl)-1H-1,2,3-triazole were the three most active compounds regarding inhibition of both tubulin polymerization and angiogenesis. Mol. modeling studies revealed that combretastatins A-1 and A-4 and analogs 5-11 could be successfully docked into the colchicine binding site of α,β-tubulin. In the experiment, the researchers used many compounds, for example, Benzo[d][1,3]dioxol-4-ol (cas: 69393-72-2Quality Control of Benzo[d][1,3]dioxol-4-ol).
Benzo[d][1,3]dioxol-4-ol (cas: 69393-72-2) belongs to alcohols. A strong base can deprotonate an alcohol to yield an alkoxide ion (R―O−). For example, sodamide (NaNH2), a very strong base, abstracts the hydrogen atom of an alcohol. Tertiary alcohols cannot be oxidized at all without breaking carbon-carbon bonds, whereas primary alcohols can be oxidized to aldehydes or further oxidized to carboxylic acids.Quality Control of Benzo[d][1,3]dioxol-4-ol
Referemce:
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