(3,4,5-Trifluorophenyl)methanol (cas: 220227-37-2) belongs to alcohols. Alcohols are weak acids. The most acidic simple alcohols (methanol and ethanol) are about as acidic as water, and most other alcohols are somewhat less acidic. A multistep synthesis may use Grignard-like reactions to form an alcohol with the desired carbon structure, followed by reactions to convert the hydroxyl group of the alcohol to the desired functionality.Synthetic Route of C7H5F3O
Identification of a 4-fluorobenzyl L-valinate amide benzoxaborole (AN11736) as a potential development candidate for the treatment of Animal African Trypanosomiasis (AAT) was written by Akama, Tsutomu;Zhang, Yong-Kang;Freund, Yvonne R.;Berry, Pamela;Lee, Joanne;Easom, Eric E.;Jacobs, Robert T.;Plattner, Jacob J.;Witty, Michael J.;Peter, Rosemary;Rowan, Tim G.;Gillingwater, Kirsten;Brun, Reto;Nare, Bakela;Mercer, Luke;Xu, Musheng;Wang, Jiangong;Liang, Hao. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2018.Synthetic Route of C7H5F3O This article mentions the following:
Novel L-valinate amide benzoxaboroles and analogs were designed and synthesized for a structure-activity-relationship (SAR) investigation to optimize the growth inhibitory activity against Trypanosoma congolense (T. congolense) and Trypanosoma vivax (T. vivax) parasites. The study identified 4-fluorobenzyl (1-hydroxy-7-methyl-1,3-dihydrobenzo[c][1,2]oxaborole-6-carbonyl)-L-valinate (5, AN11736), which showed IC50 values of 0.15 nM against T. congolense and 1.3 nM against T. vivax, and demonstrated 100% efficacy with a single dose of 10 mg/kg against both T. congolense and T. vivax in mouse models of infection (IP dosing) and in the target animal, cattle, dosed i.m. AN11736 has been advanced to early development studies. In the experiment, the researchers used many compounds, for example, (3,4,5-Trifluorophenyl)methanol (cas: 220227-37-2Synthetic Route of C7H5F3O).
(3,4,5-Trifluorophenyl)methanol (cas: 220227-37-2) belongs to alcohols. Alcohols are weak acids. The most acidic simple alcohols (methanol and ethanol) are about as acidic as water, and most other alcohols are somewhat less acidic. A multistep synthesis may use Grignard-like reactions to form an alcohol with the desired carbon structure, followed by reactions to convert the hydroxyl group of the alcohol to the desired functionality.Synthetic Route of C7H5F3O
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts