Novel series of pyrrolotriazine analogs as highly potent pan-Aurora kinase inhibitors was written by Abraham, Sunny;Hadd, Michael J.;Tran, Lan;Vickers, Troy;Sindac, Janice;Milanov, Zdravko V.;Holladay, Mark W.;Bhagwat, Shripad S.;Hua, Helen;Ford Pulido, Julia M.;Cramer, Merryl D.;Gitnick, Dana;James, Joyce;Dao, Alan;Belli, Barbara;Armstrong, Robert C.;Treiber, Daniel K.;Liu, Gang. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2011.Recommanded Product: Sodium 2-methyl-2-propanethiolate This article mentions the following:
The synthesis and SAR for a novel series of pyrrolotriazines as pan-Aurora kinase inhibitors are described. Optimization of the cyclopropane carboxamide terminus of lead compound I resulted in analogs with high cellular activity and improved rat PK profiles. Notably, pyrrolotriazine II demonstrated tumor growth inhibition in a mouse xenograft model. In the experiment, the researchers used many compounds, for example, Sodium 2-methyl-2-propanethiolate (cas: 29364-29-2Recommanded Product: Sodium 2-methyl-2-propanethiolate).
Sodium 2-methyl-2-propanethiolate (cas: 29364-29-2) belongs to alcohols. A strong base can deprotonate an alcohol to yield an alkoxide ion (R―O−). For example, sodamide (NaNH2), a very strong base, abstracts the hydrogen atom of an alcohol. Tertiary alcohols cannot be oxidized at all without breaking carbon-carbon bonds, whereas primary alcohols can be oxidized to aldehydes or further oxidized to carboxylic acids.Recommanded Product: Sodium 2-methyl-2-propanethiolate
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