Nickel-catalyzed α-alkylation of ketones with benzyl alcohols was written by Wu, Di;Wang, Yubin;Li, Min;Shi, Lei;Liu, Jichang;Liu, Ning. And the article was included in Applied Organometallic Chemistry in 2022.Recommanded Product: 873-76-7 This article mentions the following:
An efficient method for α-alkylation of ketones with benzyl alcs. using the pyridine-bridged pincer-type N-heterocyclic carbenes nickel complexes as catalysts is reported. A wide range of ketones and benzyl alcs. were efficiently converted into various alkylated products in moderate to high yields. In addition, these nickel complexes were also successfully applied for the synthesis of a wide range of quinoline derivatives In the experiment, the researchers used many compounds, for example, (4-Chlorophenyl)methanol (cas: 873-76-7Recommanded Product: 873-76-7).
(4-Chlorophenyl)methanol (cas: 873-76-7) belongs to alcohols. Alcohols are weak acids. The most acidic simple alcohols (methanol and ethanol) are about as acidic as water, and most other alcohols are somewhat less acidic. A multistep synthesis may use Grignard-like reactions to form an alcohol with the desired carbon structure, followed by reactions to convert the hydroxyl group of the alcohol to the desired functionality.Recommanded Product: 873-76-7
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts