Synthesis and preliminary evaluation of anticonvulsant activity of some [4-(benzyloxy)benzoyl]- and [4-(benzyloxy)benzyl]aminoalkanol derivatives was written by Waszkielewicz, Anna M.;Cegla, Marek;Marona, Henryk. And the article was included in Acta Poloniae Pharmaceutica in 2007.Safety of 3-Amino-3-methylbutan-1-ol This article mentions the following:
A variety of appropriate [4-(benzyloxy)benzoyl]- and [4-(benzyloxy)benzyl]aminoalkanol derivatives was synthesized and evaluated for anticonvulsant activity using the maximal electroshock (MES) and s.c. pentylenetetrazole (ScMet) tests in mice and rats. Neurotoxicity was determined by the rotorod test. The most active compounds in the MES test in mice were the appropriate 4-(benzyloxy)benzyl derivatives of (R,S)- and S-(+)-2-amino-1-butanol, 3-[4-(benzyloxy)benzyl]amino-3-methyl-1-butanol, and S-(+)-2-[4-(benzyloxy)benzyl]amino-3-methyl-1-butanol, all exhibiting 100% anti-MES protection (at 30 mg/kg, mice, i.p.) and non-toxic in the active doses. 4-[4-(Benzyloxy)benzyl]amino-1-butanol exhibited activity in both MES and ScMet (100 mg/kg, mice, i.p., 100% anticonvulsant protection, 0.5 h and 4 h after administration, resp.). In the experiment, the researchers used many compounds, for example, 3-Amino-3-methylbutan-1-ol (cas: 42514-50-1Safety of 3-Amino-3-methylbutan-1-ol).
3-Amino-3-methylbutan-1-ol (cas: 42514-50-1) belongs to alcohols. A strong base can deprotonate an alcohol to yield an alkoxide ion (R―O−). For example, sodamide (NaNH2), a very strong base, abstracts the hydrogen atom of an alcohol. Alcohols may be oxidized to give ketones, aldehydes, and carboxylic acids. These functional groups are useful for further reactions. Oxidation of organic compounds generally increases the number of bonds from carbon to oxygen (or another electronegative element, such as a halogen), and it may decrease the number of bonds to hydrogen.Safety of 3-Amino-3-methylbutan-1-ol
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts