Palladium-Catalyzed Carbonylation of Allylic Chlorides to β,γ-Unsaturated Esters/Amides under Mild Conditions was written by Wang, Peng;Cao, Zhusong.;Wang, Yaxin X.;Neumann, Helfried;Beller, Matthias. And the article was included in European Journal of Organic Chemistry in 2022.Name: (4-Chlorophenyl)methanol This article mentions the following:
Improved procedures for carbonylative transformations (alkoxy- and aminocarbonylation) of cinnamyl chloride to synthesize β,γ-unsaturated esters/amides have been developed. Studying critical reaction parameters (palladium precursors, solvents and bases) enabled the practical preparation of diverse β,γ-unsaturated esters/amides under mild conditions (low Pd catalyst loading, phosphine-free, 2 bar CO, 60°C). The optimal catalytic system shows excellent chemo- and regioselectivity for the activation of the allylic C-Cl bonds. In the experiment, the researchers used many compounds, for example, (4-Chlorophenyl)methanol (cas: 873-76-7Name: (4-Chlorophenyl)methanol).
(4-Chlorophenyl)methanol (cas: 873-76-7) belongs to alcohols. A strong base can deprotonate an alcohol to yield an alkoxide ion (R―O−). For example, sodamide (NaNH2), a very strong base, abstracts the hydrogen atom of an alcohol. A multistep synthesis may use Grignard-like reactions to form an alcohol with the desired carbon structure, followed by reactions to convert the hydroxyl group of the alcohol to the desired functionality.Name: (4-Chlorophenyl)methanol
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