Chiral manganese(IV) complexes derived from Schiff base ligands: Synthesis, characterization, in vitro cytotoxicity and DNA/BSA interaction was written by Li, Zhen;Niu, Meiju;Chang, Guoliang;Zhao, Changqiu. And the article was included in Journal of Photochemistry and Photobiology, B: Biology in 2015.Quality Control of (R)-2-Aminobutan-1-ol This article mentions the following:
Two new pairs of chiral manganese(IV) complexes with Schiff-base ligands, Λ-[Mn(R-L1)2]·2(CH3OH) (Λ–1) and Δ-[Mn(S-L1)2]·2(CH3OH) (Δ–1), Λ-[Mn(R-L2)2]·(H2O)2 (Λ–2) and Δ-[Mn(S-L2)2]·(H2O)2 (Δ–2), {H2L1 = (R/S)-(±)-1-[(1-hydroxymethyl-propylimino)methyl]naphthalen-2-ol, H2L2 = (R/S)-(±)-1-[(1-Hydroxymethyl-2-phenylethylimino)methyl]-naphthalen-2-ol} have been synthesized, and fully characterized by elemental analyses, UV-Vis spectrum, CD spectrum, FT-IR spectrum, mass spectrum, and single crystal X-ray diffraction (SXRD). The interaction of the four chiral Mn(IV) complexes with CT-DNA and BSA were also investigated by various spectroscopic techniques (UV-visible, fluorescence spectroscopic). The results show that the Δ-complexes exhibit more efficient CT-DNA interaction with respect to the Λ-complexes. All the complexes could quench the intrinsic fluorescence of BSA by a static quenching process. In addition, the vitro cytotoxicity of these complexes toward four kinds of cancerous cell lines (A549, HeLa, HL-60, and Caco-2) was assayed by the MTT method, which exhibited to be selectively active against certain cell lines. In the experiment, the researchers used many compounds, for example, (R)-2-Aminobutan-1-ol (cas: 5856-63-3Quality Control of (R)-2-Aminobutan-1-ol).
(R)-2-Aminobutan-1-ol (cas: 5856-63-3) belongs to alcohols. Alcohols are weak acids. The most acidic simple alcohols (methanol and ethanol) are about as acidic as water, and most other alcohols are somewhat less acidic. A multistep synthesis may use Grignard-like reactions to form an alcohol with the desired carbon structure, followed by reactions to convert the hydroxyl group of the alcohol to the desired functionality.Quality Control of (R)-2-Aminobutan-1-ol
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts