Preparation and antioxidant activity of α-pyridoin and its derivatives was written by Hatanaka, Masashi;Takahashi, Kyoko;Nakamura, Shigeo;Mashino, Tadahiko. And the article was included in Bioorganic & Medicinal Chemistry in 2005.SDS of cas: 49669-14-9 This article mentions the following:
Focusing on α-pyridoin (1, 1,2-di(2-pyridyl)-1,2-ethenediol) as the lead compound of the novel antioxidative enediol, we synthesized 5,5′- or 6,6′-bis-substituted derivatives of 1 from disubstituted pyridines. The antioxidant activity of 1 and its synthetic derivatives 2-7 was evaluated by DPPH (1,1-diphenyl-2-picrylhydrazyl radical) scavenging assay and inhibition of lipid peroxidation In the DPPH assay, 1 exhibited an activity stronger than that of ascorbic acid, and 5,5′-dimethyl-(5) or 5,5′-dimethoxy-substituted derivatives (6) exhibited more potent activity than 1. The DPPH scavenging activities of α-pyridoins were correlated with their oxidation potential and thus the electron d. of enediol. 5 and 6 effectively inhibited lipid peroxidation in the rat liver microsome/tert-Bu hydroperoxide system. Therefore, 5 and 6 serve as good candidates for a pharmacol. useful enediol antioxidant. In the experiment, the researchers used many compounds, for example, 2-Bromo-6-(2-methyl-1,3-dioxolan-2-yl)pyridine (cas: 49669-14-9SDS of cas: 49669-14-9).
2-Bromo-6-(2-methyl-1,3-dioxolan-2-yl)pyridine (cas: 49669-14-9) belongs to alcohols. A strong base can deprotonate an alcohol to yield an alkoxide ion (R―O−). For example, sodamide (NaNH2), a very strong base, abstracts the hydrogen atom of an alcohol. A multistep synthesis may use Grignard-like reactions to form an alcohol with the desired carbon structure, followed by reactions to convert the hydroxyl group of the alcohol to the desired functionality.SDS of cas: 49669-14-9
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts