Analysis of 44 pharmaceuticals consumed by elderly using liquid chromatography coupled to tandem mass spectrometry was written by Gomez-Canela, Cristian;Sala-Comorera, Teresa;Pueyo, Victor;Barata, Carlos;Lacorte, Silvia. And the article was included in Journal of Pharmaceutical and Biomedical Analysis in 2019.Application of 1777-82-8 This article mentions the following:
Elderly people represent about the 15% of the total world population and often include a polymedicated age group with an average consumption of 5-10 pills per day. The main pharmaceuticals consumed are antianalgesics, antidiabetics, anti-parkinson compounds, anti-convulsants, drugs to treat constipation and drugs to treat cancer. We have developed a multiresidue method for the anal. of 44 selected pharmaceuticals prioritized according to the foremost consumption by the elderly in effluents from senior residences. Given the complexity of these waters, method optimization included the selection of the extraction cartridge, pH and volume, and the optimization of the liquid chromatog.-tandem mass spectrometry conditions to minimize matrix effects and obtain high yields. Good method performance was obtained, with recoveries at 27-116% and high sensitivity. The method was tested in a preliminar study to determine pharmaceuticals released in situ from the untreated effluents of the senior residences. High concentrations were detected, with levels at 0.20-2891 μg L-1 attributed to the high consumption of drugs in the studied residences, which gather at ∼100 residents. The most detected pharmaceuticals were aspirin, macrogol, levofloxacin, cyclophosphamide, diclofenac, ibuprofen, paracetamol, carbamazepine, levetiracetam, pregabalin, quetiapine, chlormetiazole, trazodone, caffeine, 2,4-dichlorobenzyl alc. and amylmetacresol. This study describes the anal. conditions to determine the outmost consumed pharmaceuticals in wastewaters released from senior residences. In the experiment, the researchers used many compounds, for example, (2,4-Dichlorophenyl)methanol (cas: 1777-82-8Application of 1777-82-8).
(2,4-Dichlorophenyl)methanol (cas: 1777-82-8) belongs to alcohols. A strong base can deprotonate an alcohol to yield an alkoxide ion (R―O−). For example, sodamide (NaNH2), a very strong base, abstracts the hydrogen atom of an alcohol. A multistep synthesis may use Grignard-like reactions to form an alcohol with the desired carbon structure, followed by reactions to convert the hydroxyl group of the alcohol to the desired functionality.Application of 1777-82-8
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts