Infused aqueous curry tea extracts ameliorate Nω-Nitro-L-Arginine Methyl Ester-induced liver dysfunction in male albino Wistar rats was written by Ani, Franklin Ime;Nabofa, Enivwenaye Egide Williams;Omobowale, Temidayo Olutayo;Ajuzie, Nnenna Choice;Ajemigbitse, Jubilee;Oyagbemi, Ademola Adetokunbo;Attah, Alfred Francis;Adeoye, Bolade Kikelomo;Azubuike-Osu, Sharon Oluchukwu;Adedapo, Adeolu Alex;Alada, Abdul Rasak Akinola. And the article was included in Journal of Food Biochemistry in 2022.Product Details of 149-32-6 This article mentions the following:
Murraya koenigii (L.) Spreng.(Rutaceae) has been reported to pos. affect liver function. However, the effect of M. koenigii leaves on Nω-Nitro-L-Arginine Me Ester (L-NAME) induced liver dysfunction is unknown. The aim of the present study was therefore to investigate the effect of M.koenigii leaves as tea on L-NAME induced liver dysfunction. Two variants of curry tea were formulated; one was formulated entirely from leaves of M. koenigii, the other was formulated with thaumatin-rich aril obtained from seeds of Thaumatococcus danielii (Benn.) Benth. (Marantaceae). Group I animals served as control and were untreated. Groups II and V animals were administered curry tea (CT). Group III and VI animals received curry-thaumatin tea (CTT). Concurrently, L-NAME (40 mg/kg) was administered to groups IV-VI resp. for 21 days. Blood and liver samples were collected at the end of the study for biochem., histol., and immunohistochem. anal. L-NAME induced liver dysfunction evidenced by liver histol., increased activities of ALT, AST, hyperlipidemia, hepatic oxidative stress and increased hepatic NF-kB expression. Administration of CT and CTT ameliorated the L-NAME induced liver dysfunction evidenced by liver histol., increased NO hepatic bioavailability, reduced activity of ALT and AST, increased hepatic antioxidant system and decreased hepatic NF-kB expression. Thaumatin taste/flavor enhancer did not significantly reduce or potentiate the hepatoprotective, antioxidant and anti-lipidemic property of aqueous curry tea extracts in rats. L-NAME impaired liver function in rats. CT and CTT interfered with the ability of L-NAME to inhibit NO synthesis which was associated with ameliorated hepatic dysfunction. The study reports that non-selective inhibition of nitric oxide by L-NAME in rats impairs liver function and formulated curry tea types interfered with the ability of L-NAME to inhibit NO synthesis which was associated with ameliorated hepatic dysfunction in rats. In the experiment, the researchers used many compounds, for example, (2R,3S)-rel-Butane-1,2,3,4-tetraol (cas: 149-32-6Product Details of 149-32-6).
(2R,3S)-rel-Butane-1,2,3,4-tetraol (cas: 149-32-6) belongs to alcohols. Alcohols are weak acids. The most acidic simple alcohols (methanol and ethanol) are about as acidic as water, and most other alcohols are somewhat less acidic. Secondary alcohols are easily oxidized without breaking carbon-carbon bonds only as far as the ketone stage. No further oxidation is seen except under very stringent conditions.Product Details of 149-32-6
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