Sharapova, Angelica published the artcileSolubility and vapor pressure data of bioactive 6-(acetylamino)-N-(5-ethyl-1,3,4-thiadiazol-2-yl) hexanamide, Application of n-Octanol, the main research area is bioactive compound solubility elec conductivity.
This paper presents new exptl. data on some key physicochem. properties of original bioactive 6-(acetylamino)-N-(5-ethyl-1,3,4-thiadiazol-2-yl) hexanamide (AETH). Thermal anal. of the compound under study has been carried out using differential scanning calorimetry and thermogravimetric techniques. AETH solubility data in five pharmaceutically relevant solvents in the temperature range from 288.15 to 318.15 K have been obtained by the classic saturation shake-flask method. The bioactive compound has poor solubility in hexane and buffer solutions, while it is slightly soluble in selected alcs. The exptl. solubility results have been correlated by means of modified Apelblat and van’t Hoff equations. The selected thermodn. models produced acceptable results. The Hansen solubility parameters and their components for AETH and solvents have been evaluated by using the van Krevelen-Hoftyzer at. group contribution method. The ideal solubility and the solution activity coefficient at equilibrium in the selected solvents have been quantified based on exptl. values of melting enthalpy and temperature All the investigated solutions exhibit a pos. deviation from ideality with the maximal solubility in alcs. The equilibrium vapor pressure of the compound studied has been determined as a function of temperature in the range of 433.15-454.15 K by the transpiration method. The standard thermodn. parameters of AETH sublimation have been calculated
Journal of Chemical Thermodynamics published new progress about Crystals. 111-87-5 belongs to class alcohols-buliding-blocks, name is n-Octanol, and the molecular formula is C8H18O, Application of n-Octanol.
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