Katagiri, Takayuki published the artcileTrivalent metal ions promote the malic enzyme-catalyzed building of carbon-carbon bonds from CO2 and pyruvate, Recommanded Product: (S)-2-hydroxysuccinic acid, the main research area is malic enzyme carbon dioxide pyruvate aluminum iron ion carboxylation.
Malic enzyme (ME) from chicken liver (EC 1.1.1.40) is an enzyme that catalyzes the decarboxylation of malate into pyruvate and CO2 and the reverse reaction that introduces CO2 as a carboxy-group to pyruvate to form malate via oxaloacetate in the presence of natural co-enzyme NADP+/NADPH. Thus, ME is an attractive biocatalyst for building carbon-carbon bonds through the carboxylation of pyruvate with CO2. Since ME mainly catalyzes the decarboxylation of malate to produce pyruvate via oxaloacetate, it is necessary to devise ways to promote the carboxylation of pyruvate with CO2 to produce oxaloacetate based on the building of carbon-carbon bonds. Enhancing the carboxylation of pyruvate by the addition of metal ions with CO2 and using ME as a catalyst will lead to new insight into biocatalytic CO2 utilization research. The effect of adding divalent and trivalent metal ions to promote the ME-catalyzed building of carbon-carbon bonds through the carboxylation of pyruvate with CO2 was investigated. Specifically, it was found for the first time that the addition of trivalent aluminum and iron ions accelerates ME-catalyzed carboxylation of pyruvate with CO2. Moreover, it was found that a high concentration of aluminum ions (>100μM) and a low concentration of iron ions (<10μM) promote the ME-catalyzed carboxylation of pyruvate with CO2. New Journal of Chemistry published new progress about C-C bond. 97-67-6 belongs to class alcohols-buliding-blocks, name is (S)-2-hydroxysuccinic acid, and the molecular formula is C4H6O5, Recommanded Product: (S)-2-hydroxysuccinic acid.
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts