Qi, Zihe published the artcileEnhanced Cytotoxicity of Cadmium by a Sulfated Polysaccharide from Abalone, Product Details of C4H6O5, the main research area is cytotoxicity cadmium sulfated polysaccharide abalone lipid metabolism disorder; abalone gonadal polysaccharide; apoptosis; cadmium ion; cell cycle; lipidomics; metabolism.
Consumption of seafood is a common route of cadmium ion (Cd2+) exposure to consumers. The seafood matrixes may alter the toxicity profile of Cd2+ due to the interaction between Cd2+ and biomacromols. in seafood. In this study, enhanced cytotoxicity of Cd2+ was found in the presence of an abalone gonad sulfated polysaccharide (AGSP) and the mechanism was investigated at a metabolic level. The formation of the AGSP-Cd2+ complex was demonstrated by isothermal titration calorimetry. The level of reactive oxygen species (ROS) increased and mitochondrial membrane potential reduced upon exposure to the AGSP-Cd2+ complex as compared with those of Cd2+ exposure. The decreased cell viability after incubation with the AGSP-Cd2+ complex also suggested enhanced Cd2+ toxicity induced by AGSP. The metabolomics and lipidomics anal. revealed that, compared with the Cd2+ group, the AGSP-Cd2+ downregulated the phospholipid metabolism and resulted in more serious damage in the cellular membrane. The lipid metabolism disorder, in turn, amplified the generation of ROS, leading to a decrease in cell viability. These results provided new evidence of the enhanced Cd2+ toxicity upon interaction with seafood polysaccharides, and much attention should be paid to the effect of food ingredients on heavy metal ion toxicity.
Journal of Agricultural and Food Chemistry published new progress about Apoptosis. 97-67-6 belongs to class alcohols-buliding-blocks, name is (S)-2-hydroxysuccinic acid, and the molecular formula is C4H6O5, Product Details of C4H6O5.
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