Nichenko, Anna S. published the artcileLifelong Ulk1-mediated autophagy deficiency in muscle induces mitochondrial dysfunction and contractile weakness, Computed Properties of 97-67-6, the main research area is Ulk1 DRP1 BNIP3 Pink1 skeletal muscle mitochondrial dysfunction; aging; autophagy flux; mitophagy; neuromuscular junction; sarcopenia.
The accumulation of damaged mitochondria due to insufficient autophagy has been implicated in the pathophysiol. of skeletal muscle aging. Ulk1 is an autophagy-related kinase that initiates autophagosome assembly and may also play a role in autophagosome degradation (i.e., autophagy flux), but the contribution of Ulk1 to healthy muscle aging is unclear. Therefore, the purpose of this study was to investigate the role of Ulk1-mediated autophagy in skeletal muscle aging. At age 22 mo (80% survival rate), muscle contractile and metabolic function were assessed using electrophysiol. in muscle-specific Ulk1 knockout mice (MKO) and their littermate controls (LM). Specific peak-isometric torque of the ankle dorsiflexors (normalized by tibialis anterior muscle cross-sectional area) and specific force of the fast-twitch extensor digitorum longus muscles was reduced in MKO mice compared to LM mice (p < 0.03). Permeabilized muscle fibers from MKO mice had greater mitochondrial content, yet lower mitochondrial oxygen consumption and greater reactive oxygen species production compared to fibers from LM mice (p ≤ 0.04). Alterations in neuromuscular junction innervation patterns as well as changes to autophagosome assembly and flux were explored as possible contributors to the pathol. features in Ulk1 deficiency. Of primary interest, we found that Ulk1 phosphorylation (activation) to total Ulk1 protein content was reduced in older muscles compared to young muscles from both human and mouse, which may contribute to decreased autophagy flux and an accumulation of dysfunctional mitochondria. Results from this study support the role of Ulk1-mediated autophagy in aging skeletal muscle, reflecting Ulk1 0s dual role in maintaining mitochondrial integrity through autophagosome assembly and degradation International Journal of Molecular Sciences published new progress about Action potential. 97-67-6 belongs to class alcohols-buliding-blocks, name is (S)-2-hydroxysuccinic acid, and the molecular formula is C4H6O5, Computed Properties of 97-67-6.
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