Yuan, Lei published the artcileStructural characterisation and immunomodulatory activity of a neutral polysaccharide from Sambucus adnata Wall, Related Products of alcohols-buliding-blocks, the main research area is Sambucus immunomodulatory neutral polysaccharide; Immunomodulatory activity; Polysaccharide; Sambucus adnata Wall; Structure.
A neutral polysaccharide, SPW-2, was purified from the leaves of Sambucus adnata Wall. using water extraction and alc. precipitation, Sevage deproteination, ion exchange chromatog. and gel filtration chromatog. This mol. had an average mol. weight of 7040 Da and was composed of arabinose, xylose, mannose, glucose and galactose at a molar ratio of 1.5:0.5:1.2:5.0:1.8. The repetitive structural units of SPW-2 were deduced using methylation anal. and NMR (one- and two-dimensional) spectroscopy. In vitro immunol. activity test showed that SPW-2 could induce the secretion of nitric oxide, interleukin-1β (IL-1β), IL-6 and tumor necrosis factor-alpha (TNF-α), and increase the mRNA expression level of inducible nitric oxide synthase (iNOS), IL-1β, IL-6 and TNF-α in macrophages. The data supported the notion that SPW-2 exerts an immunomodulatory effect by activating macrophages and enhancing the host immune system function, which enabled it to be used as a novel immunomodulator for application in the treatment of immunol. diseases.
International Journal of Biological Macromolecules published new progress about Cytokines Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 59-23-4 belongs to class alcohols-buliding-blocks, name is (2R,3S,4S,5R)-2,3,4,5,6-Pentahydroxyhexanal, and the molecular formula is C6H12O6, Related Products of alcohols-buliding-blocks.
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