Estrada-Orihuela, Sergio F. published the artcileLasalocid immediately and completely prevents the myocardial damage caused by coronary ischemia reperfusion in rat heart, Recommanded Product: (S)-2-hydroxysuccinic acid, the main research area is lasalocid antioxidant myocardial damage coronary ischemia reperfusion; Coronary reperfusion; Heart; Lasalocid; Myocardial infarct; Myocardial ischemia.
In experiments of coronary blockade and reperfusion carried out in rat heart, it was found that when administered from 5 to 30 min prior to the induction of coronary blockade, at a concentration of 2 mg/kg of body weight, the ionophore immediately, simultaneously, and completely interrupts the blood pressure decay, cardiac frequency increase, elec. ventricular tachycardia and fibrillation, as well as the fall of mitochondrial oxidative phosphorylation and decay of mitochondrial oxygen uptake provoked by the induced myocardial injury. It appears that the mol. mode of action of the lasalocid is associated with its unique ability to transport both calcium and the catecholamines, dopamine and norepinephrine, across mitochondrial and bimol. lipid membranes, as well as through synaptic cell membrane terminals from rat heart, myocardial fibers of the heart and heart chromaffin membrane vesicles. It is suggested that for the potential medical use of lasalocid to detain incoming ischemic myocardial damage, there exists a need to develop a personal electronic device able to simultaneously monitor, detect, and inform on the very early and simultaneous signs of cardiac alterations of elec., mechano-chem., metabolic and hydraulic nature, all which precede heart failure and to administer the lasalocid.
Molecular and Cellular Biochemistry published new progress about Catecholamines Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 97-67-6 belongs to class alcohols-buliding-blocks, name is (S)-2-hydroxysuccinic acid, and the molecular formula is C4H6O5, Recommanded Product: (S)-2-hydroxysuccinic acid.
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts