Cordes, Thekla published the artcileItaconate modulates tricarboxylic acid and redox metabolism to mitigate reperfusion injury, Category: alcohols-buliding-blocks, the main research area is ischemia reperfusion injury tricarboxylic acid metabolism itaconate; Brain injury; Cerebral ischemia/reperfusion (IR); Itaconate; Mitochondrial metabolism; Redox stress; Succinate dehydrogenase (SDH).
We conducted metabolic flux and bioenergetic studies in response to exogenous itaconate treatment in cultures of primary rat cortical neurons and astrocytes. We administered itaconate to mouse models of cerebral reperfusion injury with ischemia or traumatic brain injury followed by hemorrhagic shock resuscitation. We quant. characterized metabolite levels, neurol. behavior, markers of redox stress, leukocyte adhesion, arterial blood flow, and arteriolar diameter in brains of treated/untreated mice. We demonstrate that “”immunometabolite”” itaconate slowed TCA cycle metabolism and buffered redox imbalance via succinate dehydrogenase inhibition and induction of anti-oxidative stress response in primary cultures of astrocytes and neurons. Addition of itaconate to reperfusion fluids after mouse cerebral IR injury increased glutathione levels and ROS/RNS to improve neurol. function. Plasma organic acids increased post-reperfusion injury, while administration of itaconate normalized these metabolites. In mouse cranial window models, itaconate significantly improved hemodynamics while reducing leukocyte adhesion. Itaconate supplementation increased survival in mice experiencing traumatic brain injury and hemorrhagic shock. Itaconate transiently inhibits SDH to gradually “”awaken”” mitochondrial function upon reperfusion that minimizes ROS and tissue damage. Itaconate acts as mitochondrial regulator that controls redox metabolism to improve physiol. outcomes associated with IR injury.
Molecular Metabolism published new progress about Antioxidants. 97-67-6 belongs to class alcohols-buliding-blocks, name is (S)-2-hydroxysuccinic acid, and the molecular formula is C4H6O5, Category: alcohols-buliding-blocks.
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts